*** Update March 2015 ***
The FDA issued new warnings about possible nerve damage:
Risk of nerve damage from fluoroquinolone antibiotics
This was originally published in the NY Times on Sept 10, 2012 -and originally posted August 28, 2013
Popular Antibiotics May Carry Serious Side Effects
…class of antibiotics known as fluoroquinolones. The best known are Cipro (ciprofloxacin), Levaquin (levofloxacin) and Avelox (moxifloxacin).
Adverse reactions to fluoroquinolones may occur almost anywhere in the body. In addition to occasional unwanted effects on the musculoskeletal, visual and renal systems, the drugs in rare cases can seriously injure the central nervous system (causing “brain fog,” depression, hallucinations and psychotic reactions), the heart, liver, skin (painful, disfiguring rashes and phototoxicity), the gastrointestinal system (nausea and diarrhea), hearing and blood sugar metabolism
…link to tendinitis and tendon rupture and… ability to block neuromuscular activity
These lead to especially severe and possibly permanent consequences in people with EDS, and should only be used if there are no other alternatives.
More scholarly articles on this topic:
“More on Fluoroquinolone Antibiotics and Tendon Rupture” New England Journal of Medicine, http://www.nejm.org/doi/full/10.1056/nejm199501193320319
“Partial Achilles Tendon Ruptures Associated with Fluoroquinolone Antibiotics: A Case Report and Literature Review” http://fai.sagepub.com/content/17/8/496.short
“The Effect of Ciprofloxacin On Tendon, Paratenon, and Capsular Fibroblast Metabolism” http://ajs.sagepub.com/content/28/3/364.short
“Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature” http://cid.oxfordjournals.org/content/36/11/1404.short
While none are specific to EDS, having defective collagen already puts us at risk for tendon ruptures.