Evidence of epigenetic mechanisms involved in pain states

Differential methylation of the TRPA1 promoter in pain sensitivity  – from NIH

we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals.

identifies epigenetic changes in both novel and established candidate genes that provide molecular insights into pain and may generalize to other complex traits.

Recent evidence points to the involvement of epigenetic mechanisms across these molecular systems, both in the development and maintenance of pain states

In summary, we observed strong evidence for association between DNA methylation levels and pain-sensitivity scores in a data set of 100 individuals.

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