Acetaminophen for Chronic Pain: A Systematic Review on Efficacy. – PubMed – NCBI | Basic Clin Pharmacol Toxicol. 2015 Nov
Acetaminophen (paracetamol) is the most commonly used analgesic worldwide and recommended as first-line treatment in all pain conditions by WHO.
We performed a systematic literature review to evaluate the efficacy of acetaminophen when used for chronic pain conditions.
All studies were conducted in patients with hip- or knee osteoarthritis and six out of seven studies had observation periods of less than three months.
All included studies showed no or little efficacy with dubious clinical relevance.
In conclusion, there is little evidence to support the efficacy of acetaminophen treatment in patients with chronic pain conditions. Assessment of continuous efficacy in the many patients using acetaminophen worldwide is recommended.