Acetaminophen for Chronic Pain: Review on Efficacy

Acetaminophen for Chronic Pain: A Systematic Review on Efficacy. – PubMed – NCBI | Basic Clin Pharmacol Toxicol. 2015 Nov

Acetaminophen (paracetamol) is the most commonly used analgesic worldwide and recommended as first-line treatment in all pain conditions by WHO.

We performed a systematic literature review to evaluate the efficacy of acetaminophen when used for chronic pain conditions.

All studies were conducted in patients with hip- or knee osteoarthritis and six out of seven studies had observation periods of less than three months.

All included studies showed no or little efficacy with dubious clinical relevance.

In conclusion, there is little evidence to support the efficacy of acetaminophen treatment in patients with chronic pain conditions. Assessment of continuous efficacy in the many patients using acetaminophen worldwide is recommended.

5 thoughts on “Acetaminophen for Chronic Pain: Review on Efficacy

    1. Zyp Czyk Post author

      Anyone with serious chronic pain knows this, but it’s always the first thing they recommend for pain. But when it doesn’t work for us? The next more powerful pain meds are opioids.

      It’s sad that it needed to be experimentally validated to finally be taken seriously. This will force (or at least slow down) doctors to quit pushing this poisonous drug. They make it sound like it’s guaranteed to work on every pain you may have.

      And what ever happened to “listening to the patient” who is telling you that a medicine is not working?


      1. Payne Hertz

        Stress is the cause of all pain, and Motrin is its cure. When they talk about “safe and effective” alternatives to opioids, acetaminophen, NSAIDs, anti-depressants and anti-convulsants are what they have in mind.

        I remember the very first time I went to the VA with pain so excruciating in my wrists I could barely lift a teacup. When I asked the doctor for something for the pain he said “try Tylenol.” When I told him that didn’t work he said “try Extra-Strength Tylenol.” They really believe in anything that isn’t an opioid, even a drug that says right on the label it is for “minor aches and pains.”

        Someone remind me why people without a clue get to decide what we do or don’t put in our bodies? Would you trust a nutritionist who didn’t know what a carbohydrate is or a mechanic who doesn’t know what a fuel injector does? Because that is about the level of ignorance we are dealing with much of the time.

        Liked by 1 person

  1. Wren

    I’ve wondered for decades why anyone bothers with this useless but dangerous drug. It doesn’t even relieve a minor headache, let alone the often cancer-like pain of RA. And yet it’s prescribed in opiate combos like hydrocodone, risking potentially deadly liver damage. Shame on the pharma/corporation that shills this drug, and shame on WHO for going along with them..

    Liked by 1 person

  2. Pingback: Pain management in the Ehlers–Danlos syndromes | EDS and Chronic Pain News & Info

Other thoughts?

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.