Top 10 PRF News Stories in 2015 (1 Jan 2015–21 Dec 2015):
- Synaptic Mechanism May Link Pain, Anxiety in Brain
Novel form of plasticity in the anterior cingulate cortex could provide target for treatment
- Biogen Idec Announces Plans to Buy Nav1.7 Program
Convergence Pharmaceuticals’ pain candidate gets vote of confidence
- Prelimbic Circuitry Links Chronic Pain and Anxiety
Deactivation of a specific prefrontal neuron population via kinase signaling underlies the connection
- PET Scans Provide First Evidence for Glial Activation in Brain in Chronic Pain Patients
Tracer lights up thalamus in people with lower back pain
- Glycinergic Inhibitory Interneurons in the Spinal Cord “Gate” Pain
Mouse study reveals the cells have universal effect on nociception
- The Origins of Migraine: Inside or Outside the Brain?
Neuropeptide PACAP-38 triggers sensitization of central trigeminovascular neurons in rats, but both peripheral and central mechanisms likely contribute to the condition
- The Future of Epigenetics in Pain Research
A recent PRF webinar highlighted the relevance of epigenetics to understanding chronic pain mechanisms and vulnerability and developing new analgesics
- Descending Dopaminergic Inputs to Spinal Cord Maintain Pain Plasticity
D1/D5 receptor signaling regulates maintenance of pain memory trace
- Crosstalk Between Pain and Opioid Analgesia Signaling Pathways Identified
Pro-nociceptive neurokinin 1 receptor signaling enhances mu-opioid receptor recycling
- Cortical Dendrites: A New Site for Chronic Pain Plasticity
Serotonin emerges as pain neuromodulator in anterior cingulate cortex
Top 10 Papers of the Week in 2015 (1 Jan 2015–21 Dec 2015):
- Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
- The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.
- Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain.
- Chronic back pain is associated with alterations in dopamine neurotransmission in the ventral striatum.
- Dorsal horn circuits for persistent mechanical pain.
- Evidence for brain glial activation in chronic pain patients.
- Structure of the TRPA1 ion channel suggests regulatory mechanisms.
- Selective activation of microglia facilitates synaptic strength.
- Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons.
- Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.