PRF’s Top News Stories and Papers of the Week for 2015

PRF’s Top News Stories and Papers of the Week for 2015

Top 10 PRF News Stories in 2015 (1 Jan 2015–21 Dec 2015):

  1. Synaptic Mechanism May Link Pain, Anxiety in Brain
    Novel form of plasticity in the anterior cingulate cortex could provide target for treatment
  1. Biogen Idec Announces Plans to Buy Nav1.7 Program
    Convergence Pharmaceuticals’ pain candidate gets vote of confidence
  1. Prelimbic Circuitry Links Chronic Pain and Anxiety
    Deactivation of a specific prefrontal neuron population via kinase signaling underlies the connection

  1. PET Scans Provide First Evidence for Glial Activation in Brain in Chronic Pain Patients
    Tracer lights up thalamus in people with lower back pain
  1. Glycinergic Inhibitory Interneurons in the Spinal Cord “Gate” Pain
    Mouse study reveals the cells have universal effect on nociception
  1. The Origins of Migraine: Inside or Outside the Brain?
    Neuropeptide PACAP-38 triggers sensitization of central trigeminovascular neurons in rats, but both peripheral and central mechanisms likely contribute to the condition
  1. The Future of Epigenetics in Pain Research
    A recent PRF webinar highlighted the relevance of epigenetics to understanding chronic pain mechanisms and vulnerability and developing new analgesics
  1. Descending Dopaminergic Inputs to Spinal Cord Maintain Pain Plasticity
    D1/D5 receptor signaling regulates maintenance of pain memory trace
  1. Crosstalk Between Pain and Opioid Analgesia Signaling Pathways Identified
    Pro-nociceptive neurokinin 1 receptor signaling enhances mu-opioid receptor recycling
  1. Cortical Dendrites: A New Site for Chronic Pain Plasticity
    Serotonin emerges as pain neuromodulator in anterior cingulate cortex


Top 10 Papers of the Week in 2015 (1 Jan 2015–21 Dec 2015):

  1. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
  2. The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.
  3. Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain.
  4. Chronic back pain is associated with alterations in dopamine neurotransmission in the ventral striatum.
  5. Dorsal horn circuits for persistent mechanical pain.
  6. Evidence for brain glial activation in chronic pain patients.
  7. Structure of the TRPA1 ion channel suggests regulatory mechanisms.
  8. Selective activation of microglia facilitates synaptic strength.
  9. Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons.
  10. Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.



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