Psychiatric disorders and psychosocial impairment are common, yet poorly characterized, findings in EDS patients.
We investigated the frequency and types of psychiatric disorders and their relationship to systemic manifestations in a cohort of 106 classic and hypermobility type EDS patients. In this retrospective study, extensive medical chart review was performed for patients referred at two genetics clinics who were diagnosed with EDS. Statistical analysis was undertaken to determine the frequency of psychiatric disorders and association with systemic findings
Psychiatric disorders were found in 42.5 % of the EDS cohort, with 22.7 % of patients affected with 2 or more psychiatric diagnoses.
Anxiety and depression were most commonly reported, with frequencies of 23.6 and 25.5 %, respectively.
A variety of other psychiatric diagnoses were also identified.
- Abdominal pain [odds ratio (OR) 7.38],
- neuropathic pain (OR 4.07),
- migraines (OR 5.21),
- joint pain (OR 2.85) and
- fatigue (OR 5.55)
were significantly associated with the presence of a psychiatric disorder.
The presence of any pain symptom was significantly associated with having a psychiatric disorder (OR 9.68).
- Muscle pain (OR 2.79),
- abdominal pain (OR 5.78),
- neuropathic pain (OR 3.91), migraines (OR 2.63) and
- fatigue (OR 3.78) were
were significantly associated with having an anxiety or mood disorder.
Joint hypermobility and the classic dermatological features of EDS showed no significant association with having a psychiatric disorder.
After researching pain for a few years now, it seems obvious to me, but apparently not to most researchers, that pain itself may be causing many of the “mental” side-effects in patients with all kinds of syndromes that cause pain.
Our findings demonstrate a high frequency of psychiatric disorders and an association with pain symptoms in EDS.