Skin Ultrastructural Clues on the Impact of Ehlers-Danlos Syndrome in Women – Published in Journal of Dermatological Research, 9/18/2016
Ehlers-Danlos syndrome is heterogeneous in its genetic origins, molecular defects, and ultrastructure of connective tissues (CT).
The altered mechanical functions of the involved tissues lead to variable combinations of increased skin distensibility and elasticity, joint laxity and CT fragility.
In addition, EDS women commonly suffer from some gynecologic and obstetric disorders.
Dermal ultrastructural changes show representative patterns suggesting some EDS types: the collagen and elastic fibres are altered in the dermis, ligaments, vessel walls and internal organs.
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