Researchers Identify Riskiest NSAIDs

Researchers Identify Riskiest NSAIDs — Pain News Network – By Pat Anson, Editor – September 30, 2016

A large study published in the British Medical Journal found that use of any NSAID was associated with a 20 percent higher risk of being hospitalized with heart failure.

Seven NSAIDs were found to be the riskiest, depending on the dose taken:

  • diclofenac
  • ibuprofen
  • indomethacin
  • ketorolac
  • naproxen
  • nimesulide
  • piroxicam  

In addition, two COX 2 inhibitors — etoricoxib and rofecoxib – were also associated with a higher risk of heart failure.

“Our study, based on real world data on almost 10 million NSAIDs users from four European countries, provides evidence that current use of both COX 2 inhibitors and traditional individual NSAIDs are associated with increased risk of heart failure.

Furthermore, the magnitude of the association varies between individual NSAIDs and according to the prescribed dose,” researchers reported.

The risk of heart failure doubled for people taking diclofenac, etoricoxib, indomethacin, piroxicam, or rofecoxib at very high doses. But even medium doses of indomethacin and etoricoxib were associated with increased risk.

NSAIDs are used to alleviate pain and reduce inflammation, and are found in a wide variety of over-the-counter products – from headache relievers to cold and flu remedies. They are used in so many different products — such as Advil and Motrin — that many consumers may not be aware how often they use NSAIDs.

Several previous studies have found that NSAIDs increase the risk of cardiovascular disease and other health problems, but the exact cause has been unclear.

A recent study at the University of California, Davis, found that NSAIDs reduced the activity of cardiac cells and led to cell death.

Last year the U.S. Food and Drug Administration ordered warning labels for all NSAIDs to be strengthened to indicate they increase the risk of a fatal heart attack or stroke.

The FDA said studies found the risk of serious side effects can occur in the first few weeks of using NSAIDs and could increase the longer people use the drugs.

The revised warning does not apply to aspirin.

It doesn’t surprise me that aspirin doesn’t cause damage like the later NSAIDs, because aspirin is the originally discovered naturally occurring NSAID, extracted from White Willow Bark.

Once again, a compound more closely related to those found pre-existing in nature is much less damaging than those that are chemically “derived” from them.

The same differences are found with opioids compared to other pain medications and with butter compared to margarine (which has been proven to be harmful in the newest nutritional studies).

I’m becoming convinced that compounds found in nature are more effective and better suited (less side effects) for humans. These are the ones we evolved with, so our bodies may be designed to benefit from them.


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