Individuals with major depressive disorder or bipolar disorder who receive low-field magnetic stimulation (LFMS) show immediate and substantial mood improvement,
LFMS is unlike any current treatment.
It uses magnetic fields that are a fraction of the strength but at a higher frequency than the electromagnetic fields used in TMS [transcranial magnetic stimulation] and ECT [electroconvulsive therapy],
Importantly, LFMS appears to have an immediate effect on mood and thus has the potential to provide relief in emergency situations,
Using a portable tabletop LFMS device that Rohan designed, the researchers studied 63 volunteers between the ages of 18 and 65.
All participants had been diagnosed with either major depressive disorder or bipolar disorder and had been on a regimen of antidepressants or mood-stabilizing medications for at least six weeks.
Of the study participants, 34 actively received LFMS, while the other 29 went through the process but did not actually receive any brain stimulation. Since neither the patients nor the researchers knew which participants had actually received the treatment, the true effect of the LFMS could be measured.
Participants who received the LFMS treatment indicated a marked improvement in their mood, while those whose brains were not stimulated reported no change in mood.
“We observed immediate improvement in mood following relatively brief exposure to LFMS,” noted Rohan.
“If the results described in this study are replicated in larger studies and the effects are shown to be durable, LFMS would be a welcome addition to the clinical armamentarium in the treatment of depression, may find application in other psychiatric and neurologic diseases, and may help to inform and guide us toward future directions in neuromodulation,” wrote Mouhsin Shafi, Philip Stern, and Alvaro Pascual-Leone.
additional research is already underway to find the best parameters for LFMS use in the clinical treatment of depression
He has also started a research study to evaluate the effects of multiple rather than to single treatments, and measure how long the antidepressant effects last following treatment.