So much pain research is conducted on animals that are expected to react just like humans, but this study shows how unrealistic it is to draw conclusions about humans from animal studies.
The human brain’s advanced cognitive capabilities are often attributed to our recently evolved neocortex. Comparison of human and rodent brains shows that the human cortex is
- contains more white matter,
- has larger neurons, and
- its abundant pyramidal cells (formerly called “psychic” neurons) have more synaptic connections per cell
as compared to rodents.
However, scientists have yet to determine whether there are important differences at the biophysical level of the basic building blocks of the human neocortex, the pyramidal neurons.
Do these cells possess unique biophysical properties that might impact on cortical computations?
To answer this question, a theoretical team led by Prof. Idan Segev from the Hebrew University of Jerusalem, working with experimental colleagues at Vrije Universiteit Amsterdam and Instituto Cajal in Madrid, built detailed 3D models of pyramidal cells from the human temporal neocortex. These first-ever detailed models of human neurons were based on in vitro intracellular physiological and anatomical data from human cells.
The theoretical study predicted that layer 2/3 pyramidal neurons from the human temporal cortex would have a specific membrane capacitance that is half of the commonly accepted “universal” value for biological membranes (~0.5 µF/cm2 vs. ~1 µF/cm2).
Since membrane capacitance affects how quickly a cell can respond to its synaptic inputs, this finding has important implications for the transmission of signals within and between cells.
The theoretical prediction regarding the specific membrane capacitance was then validated experimentally by direct measurements of membrane capacitance in human pyramidal neurons.
“This is the first direct evidence for the unique electrical properties of human neurons,” said researcher Guy Eyal, a Ph.D. student at the Hebrew University’s Department of Neurobiology.
“Our finding shows that low membrane capacitance significantly improves the efficacy of signal processing and the speed of communication within and between cortical neurons in the human neocortex, as compared to rodents.”
“Indeed, the study shows that already at the level of the individual building blocks of the nervous system (the nerve cells), humans are distinct as compared to rodents. More research should be performed in this direction on non-human primates.”
The researchers suggest the distinctive biophysical membrane properties of human pyramidal neurons are an outcome of evolutionary pressure to compensate for the increase in size and distances in the human brain.