Ehlers-Danlos Syndrome from MedlinePlus.gov – a trusted site of the NIH with factual information (scientific and rarely wrong, not commercial, promotional, or fake)
Ehlers-Danlos syndrome (EDS) is a group of inherited disorders that weaken connective tissues. Connective tissues are proteins that support skin, bones, blood vessels, and other organs.
This means that EDS can affect almost any function of your body.
EDS usually affects your skin, joints and blood vessel walls.
- Loose joints
- Fragile, small blood vessels
- Abnormal scar formation and wound healing
- Soft, velvety, stretchy skin that bruises easily
There are several types of EDS. They can range from mild to life-threatening. About 1 in 5,000 people has EDS.
There is no cure.
Treatment involves managing symptoms, often with medicines and physical therapy. It also includes learning how to protect your joints and prevent injuries.
Collagen types associated with Ehlers-Danlos:
Colagen Type I
- This is the most abundant collagen of the human body. It is present in scar tissue, the end product when tissue heals by repair. It is found in tendons, skin, artery walls, cornea, the endomysium surrounding muscle fibers, fibrocartilage, and the organic part of bones and teeth.
- Gene(s): COL1A1, COL1A2
- Disorders: Osteogenesis imperfecta, Ehlers–Danlos syndrome, Infantile cortical hyperostosis a.k.a. Caffey’s disease
Colagen Type III
- This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. Reticular fiber. Also found in artery walls, skin, intestines and the uterus
- Gene(s): COL3A1
- Disorders: Ehlers–Danlos syndrome, Dupuytren’s contracture
Colagen Type V
- Most interstitial tissue, assoc. with type I, associated with placenta
- Gene(s):COL5A1, COL5A2, COL5A3
- Disorders: Ehlers–Danlos syndrome (Classical)
- Ehlers-Danlos Syndrome(Mayo Foundation for Medical Education and Research)
- Ehlers-Danlos syndrome (Medical Encyclopedia)Also in Spanish
- Ehlers-Danlos Syndrome Hypermobility Type(Marfan Foundation) – PDF
- Ehlers-Danlos Syndrome: Causes and Symptoms(Ehlers-Danlos Syndrome Network C.A.R.E.S.)
- Ehlers-Danlos Syndrome: Myths and Facts(Ehlers-Danlos Syndrome Network C.A.R.E.S.)
- Heritable Disorders of Connective Tissue (National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- Genetics Home Reference: Ehlers-Danlos syndrome (National Library of Medicine)
- ClinicalTrials.gov: Ehlers-Danlos Syndrome (National Institutes of Health)
References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility…
- Article: Defect in dermatan sulfate in urine of patients with Ehlers-Danlos…
- Article: P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and…
- Ehlers-Danlos Syndrome — see more articles