Here are some Cochrane reviews on the efficacy (or lack thereof) of gabapentin (Neurontin) and pregabalin (Lyrica):
- Gabapentin for Chronic Neuropathic Pain
- Pregabalin for Fibromyalgia
- Pregabalin for Acute and Chronic Pain in Adults
- Pregabalin for Chronic Neuropathic Pain in Adults
These medications seem mildly effective for their FDA-approved conditions, but much less so for chronic pain. Yet… I’ve found Lyrica helpful for episodic pain flares when I take it on an “as needed” basis.