Risk of Opioid Medication Discontinuation

Opioid medication discontinuation and risk of adverse opioid-related health care events. – PubMed 2019 Aug

Between 2012 and 2017, the United States dramatically reduced opioid prescribing rates.

While this may be appropriate given the opioid epidemic, there has been little research to guide the clinical practice of discontinuing patients from opioid medications and opioid death rates have continued to increase.

These forced tapers have been a horrible experiment on thousands of people, enacted without any knowledge of what the outcome might be.  

To determine the relationship between time to opioid discontinuation and the risk of an opioid-related emergency department visit or hospitalization among high dose opioid users.

We applied Cox proportional hazard models to 2013-2017 Medicaid claims data to research this relationship.

Medicaid beneficiaries in Vermont who filled prescription opioids at high daily doses (at least 120 morphine milligram equivalents) for 90 or more consecutive days and who subsequently discontinued opioid prescriptions (n = 494).

The outcome was an opioid-related adverse event defined as an emergency department visit or hospitalization with a primary or secondary diagnosis of opioid poisoning or substance use disorder.


The median length of time to discontinuation was 1 day indicating that half of patients had no dose reduction prior to discontinuation.

  • 86% of patients discontinued within 21 days (considered rapid tapering in recent clinical guidelines). [these patients did not “discontinue”, their doctors did]
  • 49% of members had an opioid-related hospitalization or emergency department visit.

After controlling for sociodemographic and clinical factors, each additional week of discontinuation time was associated with a 7% reduction in the probability of having opioid related adverse event (p < 0.01).

Although 60% of members had a diagnosed substance use disorder prior to tapering, <1% of beneficiaries were transitioned onto an opioid use disorder medication.

If 60% of the subjects had SUD, they are far from the “average” pain patient. This study would then apply mostly to people addicted to opioids, not those using them for pain relief.


Faster rates of opioid tapering were associated with a greater probability of adverse events and many patients discontinued opioids suddenly, with no dose reduction.

Additional clinical guidance, research, and interventions are needed to ensure that patients’ opioid prescriptions are discontinued safely.

Yet there’s hardly any discussion about a medical reason for these potentially lethal tapers. Why must all these people be tapered from their opioid prescriptions if they have been effective and haven’t caused them problems?

This article is very similar to another one that exposes the danger of forced tapers: Mortality After Discontinuation of Opioid Therapy for Pain

Instead of wondering how to discontinue opioids we should be asking the question of why we need to discontinue a drug that has been so effective.

2 thoughts on “Risk of Opioid Medication Discontinuation

  1. Pingback: Pain Awareness IS Suicide Prevention | EDS and Chronic Pain News & Info

  2. canarensis

    “While this may be appropriate given the opioid epidemic…”

    Well, they put their bias right there at the front, at least. It’d be appropriate IF prescribing rates had anything to do with the so-called epidemic. Yet the very excellent graph published on this very site sure makes it clear that’s not the case. (https://edsinfo.wordpress.com/2019/01/09/overdose-deaths-not-correlated-with-prescribing-rates/)

    Ah, but that’s just facts. Do they matter any more?

    Liked by 1 person


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