Testosterone for severe knee Osteoarthritis

Total serum testosterone and WOMAC pain and function among older men and women with severe knee OA – Freystaetter – – Arthritis Care & Research – Wiley Online LibrarySep 2019

I’m just showing the abstract here, but a watermarked pre-publication version of the full article is available at: https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.24074

Objectives

We investigated if serum total testosterone (T)‐level is associated with knee pain and function in men and women with severe knee osteoarthritis (OA).  

Methods

We enrolled 272 adults ≥60 years (70.4±4.4 years, 53% women) who underwent unilateral total knee replacement (TKR) due to severe knee OA.

Serum T‐levels and WOMAC pain and function of the operated and contra‐lateral knee were measured at 6‐8 weeks after surgery.

At the non‐operated knee, 56% participants had radiographic knee OA with a Kellgren‐Lawrence grade ≥2. Cross‐sectional analyses were performed by gender and BMI subgroups using multivariable regression adjusted for age, physical activity and BMI.

I don’t know what the above paragraph means, but perhaps some of my readers do.

Results

At the operated knee, higher T‐levels were associated with

  • less WOMAC pain in men (B = ‐0.62; P = 0.046) and women (B = ‐3.79; P = 0.02), and
  • less WOMAC disability scores in women (B = ‐3.62; P = 0.02) and obese men (B = ‐1.99; P = 0.02).

At the non‐operated knee, T‐levels were not associated with WOMAC pain in men or women, but higher T‐levels were associated with less disability in women (B = ‐0.95; P = 0.02).

T‐levels were inconsistently associated with pain and disability in BMI subgroups among men. Only among obese women, T‐levels were inversely associated with radiographic knee OA (OR = 0.10; P = 0.003).

Conclusions

Higher total T‐levels were associated with less pain in the operated knee in men and women undergoing TKR and less disability in women.

At the non‐operated knee, higher T‐levels were inconsistently associated with less pain and disability.

1 thought on “Testosterone for severe knee Osteoarthritis

  1. canarensis

    Interesting. If testosterone helps with all pain issues, might that help explain why something like 80% of CPPs are female? Wonder if women would have less pain if they took supplemental testosterone. Tho I wouldn’t be eager to grow a mustache to find it out….tho I guess there’s always tweezers & facial hair bleach.

    Liked by 1 person

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