Objective:To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom… and to explore risk factors associated with mortality in hospital.
Design:Prospective observational cohort study with rapid data gathering and near real time analysis.
Setting: 208 acute care hospitals in England, Wales, and Scotland between 6 February and 19 April 2020.
A case report form developed by ISARIC and WHO was used to collect clinical data. A minimal follow-up time of two weeks (to 3 May 2020) allowed most patients to complete their hospital admission.
Participants: 20,133 hospital inpatients with covid-19.
Main outcome measures: Admission to critical care (high dependency unit or intensive care unit) and mortality in hospital.
The median age of patients admitted to hospital with covid-19, or with a diagnosis of covid-19 made in hospital, was 73 years (interquartile range 58-82, range 0-104).
More men were admitted than women (men 60%, n=12 068; women 40%, n=8065).
The median duration of symptoms before admission was 4 days (interquartile range 1-8).
The commonest comorbidities were
- chronic cardiac disease (31%, 5469/17 702),
- uncomplicated diabetes (21%, 3650/17 599),
- non-asthmatic chronic pulmonary disease (18%, 3128/17 634), and
- chronic kidney disease (16%, 2830/17 506);
23% (4161/18 525) had no reported major comorbidity.
- 41% (8199/20 133) of patients were discharged alive,
- 26% (5165/20 133) died, and
- 34% (6769/20 133) continued to receive care at the reporting date.
17% (3001/18 183) required admission to high dependency or intensive care units; of these,
- 28% (826/3001) were discharged alive,
- 32% (958/3001) died, and
- 41% (1217/3001) continued to receive care at the reporting date.
Of those receiving mechanical ventilation,
- 17% (276/1658) were discharged alive,
- 37% (618/1658) died, and
- 46% (764/1658) remained in hospital.
Increasing age, male sex, and comorbidities including
- chronic cardiac disease,
- non-asthmatic chronic pulmonary disease,
- chronic kidney disease,
- liver disease and
were associated with higher mortality in hospital.
ISARIC WHO CCP-UK is a large prospective cohort study of patients in hospital with covid-19.
The study continues to enrol at the time of this report.
In study participants, mortality was high, independent risk factors were increasing age, male sex, and chronic comorbidity, including obesity.
This study has shown the importance of pandemic preparedness and the need to maintain readiness to launch research studies in response to outbreaks.
The above is only from the abstract, but this is a free full-text article with excellent graphs and visualizations of the current situation.
Here’s an excellent graph and visualization of the symptoms they saw:
There are many more of these – the article is worth a look: