EDS Scientific Reference Links

Here are links to articles in the blog with annotated scientific publications relating to various aspects of Ehlers-Danlos Syndrome (EDS)

General Info

• The Ehlers-Danlos National Foundation
• EDS 2014 Physicians Conference Slides Available
• Reference: Ehlers-Danlos Syndrome, Hypermobility Type – Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Pain

• Pain in ehlers-danlos syndrome is common – large study – “Pain in Ehlers-Danlos Syndrome Is Common, Severe, and Associated with Functional Impairment”
• Impact of pain with EDS
• Management of pain and fatigue in EDS Hypermobility type – “EDS-HT is considered to be a severe chronic musculoskeletal disorder.“

Headaches & CerebroSpinal Fluid pressure

• Ehlers-Danlos and Cerebrospinal Fluid Problems
• Headaches from spontaneous spinal CSF leaks and intracranial hypotension – Both high & low CSF pressure can cause headaches

EDS and POTS/Dysautonomia

• Dysautonomia linked to Ehlers-Danlos syndrome
• EDS and Postural Tachycardia Syndrome
• POTS: Association with EDS and Orthopaedic Considerations.

Neurologic and Neuromuscular Features of EDS

• Neurological manifestations of Ehlers-Danlos Syndrome
• Neuromuscular features of Ehlers-Danlos syndrome

EDS and “Benign Joint Hypermobility Syndrome”

• Benign Hypermobility Syndrome vs EDS – This excellent summary writeup is by Shani Weber.
• Joint hypermobility syndrome: easily missed? – JHS is indistinguishable from the hypermobility type of Ehlers-Danlos syndrome
• Dermal Ultrastructure in Low Beighton Score EDSH & BJHS – Skin studies show “Benign Joint Hypermobility Syndrome” and EDS patients both had dermal abnormalities that could eventually be used for diagnosis.

Relationship to anxiety and depression

• Brain Structure and Joint Hypermobility (EDS) – Hypermobility/EDS leads to not only physical instability, but emotional/mental instability as well, and more severe Hypermobility corresponds to greater differences in brain structure.

Relationship to other disorders

• EDS III: possible unifying concept for various functional somatic syndromes – This excellent article  explains all the possible syndromes that could be caused by or related to Hypermobility, like Fibromyalgia, POTS, and Chronic Fatigue

Connective Tissue

• Study of connective tissue is shedding light on pain – many systems of the body may be affected by mechanical changes in connective tissue
• Understanding Your Fascia – Fascia is made up primarily of densely packed collagen fibers that create a full body system
• Collagen: More Powerful Than Muscle