Category Archives: Chronic Pain

List of Peer Reviewed Articles on Pain/Opioids

Peer-reviewed articles (2006-2019) on Pain/Opioids by Stefan Kertesz  (Twitter: @StefanKertesz)  June 2019

This is a collection of 26 scientifically correct (not anti-opioid) information that can be used as references to rebut the anti-opioid propaganda. Dr. Kertesz has been a powerful and respected advocate for us for many years and seems to be publishing voluminously.

Many of the articles below I’ve already posted, but here they are in a unified list of publications, most with links, which challenge the anti-opioid zealotry.   Continue reading

Can Tech ‘Objectively’ Assess Pain?

Can Tech ‘Objectively’ Assess Pain?Wired.comby Emma Grey Ellis  – May 2019

Pain flickers across people’s faces in inconsistent, contradictory ways. And the experience of pain differs just as widely as its expression—tolerance is a matter of genetics and life experience. What’s agony for you may be merely uncomfortable for someone else.

Ambiguity has always made pain assessment an inexact science for health care providers, which in turn frustrates the sufferers themselves.

Even for myself, I find trying to rate my pain a very slippery process, depending on exactly what I’m looking for (does it hurt more than usual? how much does it usually hurt? does this pain hurt more than the other pain?).  Continue reading

Weak Motor Cortex may lead to Pain in FM & ME/CFS

Bad Engine? Is a Wimpy Motor Cortex Causing the Pain in Fibromyalgia (and ME/CFS)? – Health Risingby Cort Johnson | Apr 2019

Studies suggest it’s possible that every [problematic] aspect of muscle activity – from oxygen uptake by the muscles, to mitochondrial functioning, to lactate build up, to the ability of the muscles to relax, to problems with the microcirculationare present to some degree in fibromyalgia.

Every time you pick up a pen, hit a key on a keyboard, or turn on your smartphone, the premotor and supplementary motor areas of your motor cortex plan the movement first

Then your primary motor cortex sends a message to the muscles to act.    Continue reading

Individual Differences in Pain

Individual Differences in Pain: Understanding the Mosaic that Makes Pain Personalfree full-text article /PMC5350021/

This study, in the full text (link above), contains direct quotes from interviews of the patients. It was interesting to get such a  close-up look into other people’s pain.

The experience of pain is characterized by tremendous inter-individual variability.

Multiple biological and psychosocial variables contribute to these individual differences in pain, including demographic variables, genetic factors, and psychosocial processes.

Similarly, both genetic and psychosocial factors contribute to clinical and experimental pain responses. Importantly, these different biopsychosocial influences interact with each other in complex ways to sculpt the experience of pain.   Continue reading

Chronic pain is associated with a brain aging biomarker

Chronic pain is associated with a brain aging biomarker in community-dwelling older adults: PAINPAINMay 2019 – Research Paper

This “finding” doesn’t surprise me one bit; my mental faculties have long been deteriorating faster than others in my cohort.

Chronic pain is associated with brain atrophy with limited evidence on its impact in the older adult’s brain.

We aimed to determine the associations between chronic pain and a brain aging biomarker in persons aged 60 to 83 years old

Individuals with chronic pain (n = 33) had “older” brains for their age compared with those without.    Continue reading

Not All Pain Is the Same: Extent of High-Impact Chronic Pain

Not All Pain Is the Same: Characterizing the Extent of High-Impact Chronic – Epidemiological findings highlight the need for patient-centered care –  by Stephani Sutherland – Apr 2019

Chronic pain exacts a huge toll on patients, healthcare systems, and the economy. But the way that chronic pain is typically defined—by how long it lasts—provides little information about

  1. the people suffering from chronic pain,
  2. the degree to which they are affected, and
  3. how to best treat them.

These days, chronic pain seems defined mostly by how many milligrams of an opioid need to be taken to make it bearable. The patient’s specific condition is considered irrelevant.

This is a sad side effect of medical pain: because it is only perceptible to the patient suffering from it, the easily accessible numerical measure of medication is used instead (scientific laziness, bordering on fraud).  Continue reading

Reducing the global burden of chronic pain

Reducing the global burden of chronic pain – Beth D. Darnall, Clinical Professor, Stanford University School of Medicine

The profound global burden of chronic pain is increasing as the world population ages, and particularly so for low and middle income countries.

Reducing the global burden of pain requires

  • national policy and investment to develop coordinated local, national and international efforts to improve professional and public pain education;
  • promotion of the biopsychosocial model of evidence-based pain care;

However, the biopsychosocial model is based on poor or biased evidence. Many pain patients ultimately respond only to the effectiveness of opioid therapy.  Continue reading

Opioids Proven Necessary for Sickle Cell Disease

University of Minnesota Researchers Study Effect of Chronic Opioid Therapy on Pain and Survival in Sickle Cell Disease | Medical School – University of MinnesotaAuthor: Krystle Barbour – April 2, 2019

New UMN research recently published in Blood Advances, Kalpna Gupta, PhD, Professor of Medicine, University of Minnesota Medical School, demonstrates the impact of opioids on the survival of humanized mouse models with sickle cell disease, compared to normal mice.

Sickle Cell Disease (SCD) affects millions of people throughout the world. The genetic disease worsens over time and can cause lifelong pain.

Given the often severe nature of the pain associated with SCD opioid use is a rule not an exception for treatment.

Unfortunately, I’ve read several accounts of patients with documented SCD not being allowed opioids, even when in a crisis.  Continue reading