Here’s everything you ever wanted to know about fentanyl, the ultra-strong opioid first synthesized in 1960 for IV medical use.
This article explains the history and the rationale for using this particular opioid medically in transdermal patches (continuous dose) and sublingual wafers (immediately effective).
Unfortunately, even in 2014, it seems the scientific community was unaware that fentanyl was and is being illicitly manufactured for sale on the black market. It is this illicit fentanyl that’s causing so many overdoses due to its extreme potency and poorly controlled careless handling. Continue reading →
For most people, pain eventually fades away as an injury heals. But for others, the pain persists beyond the initial healing and becomes chronic, hanging on for weeks, months, or even years.
Now, we may have uncovered an answer to help explain why: subtle differences in a gene that controls how the body responds to stress.
In a recent study of more than 1,600 people injured in traffic accidents, researchers discovered that individuals with a certain variant in a stress-controlling gene, called FKBP5, were more likely to develop chronic pain than those with other variants. Continue reading →
Tapentadol prolonged release (PR) for the treatment of moderate to severe chronic pain combines 2 modes of action.
These are μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule that allow higher analgesic potency through modulation of different pharmacological targets within the pain-transmitting systems. Continue reading →
I’ve learned that some of my pain of musculoskeletal origin can be ameliorated by strengthening weaker muscles and aligning my spine better.
For years, I had a severe problem with recurring cervicogenic headaches, which were probably caused by a pinch somewhere in my hypermobile cervical spine. But after doing Isometric exercises with my neck my vertebrae realign properly and I don’t get the headaches anymore.
Easing pain strikes me as an elemental human endeavor. But… doing so can be complex and nuanced in ways that much of medical treatment is not.
Inadequate pain treatment, termed oligoanalgesia, was recognized by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) in 2001 as a public health problem.
Across health care settings, pain is undertreated; the ED is no exception [2-6]. Physicians and nurses consistently underestimate the pain experienced by ED patients, which means that some leave the ED with little if any relief. Continue reading →
Though this article is almost a year old, it points out that empathy is still a healing force, despite its recent demonization for supposedly promoting a patient’s “catastrophizing“.
While it may be common sense that everyday interpersonal experiences play a role in the link between close relationships and physical health, few studies have been able to make any firm conclusions. Recently, however, researchers set out to close the gap in what is known about how spouses’ responses may or may not affect long-term physical functioning.
The research team, based at Penn State University, examined the association between the expression of pain made by patients with knee osteoarthritis and how their spouses responded to it, and changes in the patients’ physical function over 18 months. Continue reading →
Given the current state of knowledge regarding long-term opioid treatment, we suggest that dilemmas associated with this treatment are best approached using patient-centered clinical ethics.
We believe principle-based, deontological, and classical Hippocratic ethical approaches have less relevance in sorting out current controversies surrounding opioid treatment.
Indeed, effective medical treatment should always be “patient-centered” and not predetermined by some rules invented by politicians seeking to take advantage of this collective cultural insanity to increase their power. Continue reading →