MSM, Oxidative Stress, Muscle Damage, and Pain

Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial  – free full-text PMC5521097 – 2017 Jul

Oxidative stress and muscle damage occur during exhaustive bouts of exercise, and many runners report pain and soreness as major influences on changes or breaks in training regimens, creating a barrier to training persistence.

Methylsulfonylmethane (MSM) is a sulfur-based nutritional supplement that is purported to have pain and inflammation-reducing effects.

To investigate the effects of MSM in attenuating damage associated with physical exertion, this randomized, double-blind, placebo-controlled study evaluated the effects of MSM supplementation on exercise-induced pain, oxidative stress and muscle damage.   Continue reading

Doctors over-prescribing seizure drugs to treat pain

Doctors may be over-prescribing seizure drugs to treat pain – chicagotribune.com – Dennis Thompson – Aug 2017

Physicians might be relying too heavily on “off-label” use of epilepsy drugs as an alternative to prescribing narcotic painkillers, two experts in internal medicine contend.

Doctors are prescribing the anti-seizure drugs gabapentin (Neurontin) and pregabalin (Lyrica) to treat pain more frequently, partly in response to the opioid epidemic in the United States, said Dr. Allan Brett. He’s a professor of clinical internal medicine with the University of South Carolina School of Medicine in Columbia.

However, the drugs might not be doing any good for many people suffering from chronic pain, Brett said.  Continue reading

Half of “low intensity” CBT clients relapse within 12 months

False economy? Half of “low intensity” CBT clients relapse within 12 months – By Christian Jarrett

Heralded as a revolution in mental health care – a cost-effective way to deliver evidence-based psychological help to large numbers – low-intensity Cognitive Behavioural Therapy (CBT) is recommended by NICE, the independent health advisory body in England and Wales, for mild to moderate depression and anxiety.

Prior studies into its effectiveness have been promising. However, little research has looked at whether the benefits last.

A new study in Behaviour Research and Therapy has done that, following a cohort of people with depression and anxiety over time.   Continue reading

Researcher finds antidote to health bullshit

This researcher may have discovered the antidote to health bullshit – Vox – by Julia Belluz and Alvin Chang – Jul 17, 2017,

Andy Oxman is obsessed with the study of bullshit health claims and how to prevent them from spreading.

Oxman, now the research director at the Norwegian Institute of Public Health, started to wonder whether the best hope for bullshit prevention lay with children.

The little classroom visit convinced Oxman he had to start schooling people in the ways of bullshit detection early in life.

So he began working with other researchers from around the world to develop curricula — a cartoon-filled textbook, lessons plans — on critical thinking skills aimed at school children.   Continue reading

Mainstream Medicine Smitten by Hocus-Pocus

Mainstream medicine is partly to blame for the ‘treatments’ Goop promotes By Arthur Caplan and Timothy Caulfield – August 2, 2017

It is easy to mock the ridiculous and potentially harmful health advice and product lines promoted by Gwyneth Paltrow and her team at Goop.

Sleeping near healing crystals, lugging around jade eggs in the vagina, swilling moon juice, undergoing raw goat milk cleanses, dabbing on sex dust, and snapping photos of your aura are just some of the ridiculous treatments and remedies offered at high prices to those looking for health ideas from a movie star.

How does this company and other equally daffy outfits pull off these highly lucrative health scams?

Mainstream medicine is partly to blame.   Continue reading

Applications and Safety of Methylsulfonylmethane (MSM)

Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement –  free full-text PMC5372953

Description and History of MSM

Methylsulfonylmethane (MSM) is a naturally occurring organosulfur compound. Prior to being used as a clinical application, MSM primarily served as a high-temperature, polar, aprotic, commercial solvent, as did its parent compound, dimethyl sulfoxide (DMSO).

Throughout the mid-1950s to 1970s, DMSO was extensively studied for its unique biological properties including its membrane penetrability with and without the co-transport of other agents,

  • its antioxidant capabilities,
  • its anti-inflammatory effects,
  • its anticholinesterase activity, and
  • its ability to induce histamine release from mast cells  Continue reading

ADHD and reward deficiency syndrome

This PubMed article piqued my interest because of the following paragraphs which seem an uncanny description of the hyper-sensitivity that so many of us suffer from.

It may be that people with ADHD are afflicted with a defective filtering system such that their brainstem reticular formation does not block out irrelevant stimuli. These people appear to be aware of every sound, every object, every touch, and they all merge in disorganized behaviors that are difficult to tolerate

At a deeper level, ADHD is a problem of communication among brain cells, or neurons, possibly involving the neurotransmitters that carry inter-neural messages. If the messengers that inhibit incoming stimuli are deficient, too many signals get through and create confusion.

Attention-deficit-hyperactivity disorder and reward deficiency syndrome – free full-text PMC2626918 – 2008 Oct;   Continue reading

Being Judged: The Swinging Pendulum and Pain Mgmt

Being Judged:The Swinging Pendulum and Pain Management  Kathleen Hoffman on Apr 10, 2017

Did you know that before the year 2000, poor pain management was called a major medical problem and was synonymous with poor medical care in the US?

On January 1, 2001, Congress declared 2001 to 2010 the Decade of Pain Control and Research.

Assuring that effective pain management occurred in hospitals, in 2003, the Joint Commission on Accreditation of Healthcare Organizations (JCOH) added pain management criteria to the requirements they establish for hospital accreditation.   Continue reading

A Tiny Tweak to Gut Bacteria Can Extend an Animal’s Life

A Tiny Tweak to Gut Bacteria Can Extend an Animal’s Life – The Atlantic – Ed Yong –  JUN 15, 2017

Most of the worms in Meng Wang’s lab die on schedule. They live their brief lives on Petri dishes, and after two to three weeks, they die of old age.

But some individuals beat the odds, surviving for several days longer than usual.These wormy Methuselahs were all genetically identical, so it wasn’t their genes that explained their decelerated aging. Instead, the secret to their longevity lay in the microbes within their gut.

This is part of a growing number of studies showing that an animal’s microbiome—the community of microbes that shares its body—can influence its lifespan.   Continue reading

Duration of Antibiotic Therapy: General Principles

Duration of Antibiotic Therapy: General Principles – Pharmacy Times – Maricelle O. Monteagudo-Chu, PharmD, BCPS-AQID, and Nageh Shaeishaa, RPH, MSC – July 2017

Deciding on the duration of antimicrobial therapy for an infection is neither straightforward nor simple. A short or long course of antibiotics can be given to a patient, depending on the drug used, the severity of an infection, and response to treatment (Table 1).

Original image is blurry too 

Continue reading