Hotter bodies fight infections and tumors better — researchers show how — ScienceDaily – May 21, 2018 – Source: University of Warwick
I’ve always wondered about this: if our bodies deliberately start a fever to fight an infection, why do we always want to lower it? Now it looks like fevers also help with
The hotter our body temperature, the more our bodies speed up a key defense system that fights against tumors, wounds or infections
The researchers have demonstrated that small rises in temperature (such as during a fever) speed up the speed of a cellular ‘clock’ that controls the response to infections — and this new understanding could lead to more effective and fast-working drugs which target a key protein involved in this process. Continue reading
Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection – Science Direct – Feb 2018 – free full-text article
I just found this interesting: the body fat cells that we so want to get rid of actually have a critical role in wound healing.
- Fat body cells actively migrate to wounds using a peristaltic mode of motility
- Fat body cells tightly seal the gap by forming lamellipodia around the wound margin
- Fat body cells collaborate with macrophages to clear wound debris
- Fat body cells locally release antimicrobial peptides at infected wounds
Pain Affects Visual Orientation: an Eye-Tracking Study – Journal of Pain – February 2018
Because of its unique evolutionary relevance, it is understood that pain automatically attracts attention.
So far, such attentional bias has mainly been shown for pain-related stimuli whereas little is known about shifts in attentional focus after actual painful stimulation.
Our bodies were designed to respond immediately to pain. To remedy the situation causing it is our prime directive. This cannot be easily overruled by design and calling it “catastrophizing” does not ease its urge to action. Continue reading
The mysterious rise in knee osteoarthritis – Harvard Health Blog – Harvard Health Publishing
Osteoarthritis is the form of joint disease that’s often called “wear-and-tear” or “age-related,” although it’s more complicated than that.
While it tends to affect older adults, it is not a matter of “wearing out” your joints the way tires on your car wear out over time. Your genes, your weight, and other factors contribute to the development of osteoarthritis.
Since genes don’t change quickly across populations, the rise in prevalence of osteoarthritis in recent generations suggests an environmental factor, such as activity, diet, or weight. Continue reading
The thoracolumbar fascia: anatomy, function and clinical considerations – free full-text /PMC3512278/ – J Anat. – 2012 May 27.
In this overview, new and existent material on the organization and composition of the thoracolumbar fascia (TLF) will be evaluated in respect to its anatomy, innervation biomechanics and clinical relevance.
The integration of the passive connective tissues of the TLF and active muscular structures surrounding this structure are discussed, and the relevance of their mutual interactions in relation to low back and pelvic pain reviewed.
The TLF is a girdling structure consisting of several aponeurotic and fascial layers that separates the paraspinal muscles from the muscles of the posterior abdominal wall. Continue reading
Cervicogenic Headache – Physiopedia
Due to our overly-stretchable tendons and ligaments, we with EDS often get these headaches that arise from misalignments of our upper cervical spine.
Cervicogenic headache is a chronic headache that arises from the atlanto-occipital and upper cervical joints and perceived in one or more regions of the head and/or face
Could My Feet Be Causing My Chronic Pain? – By Lisa Ellis – Apr 1017
Dr. Rothbart has an intriguing approach to foot pain, using insoles to shift the positioning of the foot to alter the signals it sends to the brain.
A healthy foot sends signals to the brain, which is used to regulate posture, says Brian A. Rothbart, DPM, PhD.
When the foot is structurally unstable, as in these two foot structures, the signals are distorted and bad posture results.
When the body is not properly aligned, it can cause related muscle and joint pain. Continue reading
Editor’s Memo: Spinal Fluid Flow and Pain Management – practicalpainmanagement.com – Editor’s Memo June 2017 By Forest Tennant, MD, DrPH
Spinal fluid flow (SFF) [also called cerebrospinal fluid, CSF] has been a silent subject in pain management.
This has to change.
For a while, pain practitioners have unknowingly been utilizing a variety of measures that likely enhance SFF.
Progressive research that involves SFF has shown how it occurs, how it may promote pain, and how it may impede treatment efforts. Continue reading
What is Piriformis Syndrome? spine-health.com – By John P. Revord, MD – Sept 2012
Piriformis syndrome is a condition in which the piriformis muscle, located in the buttock region, spasms and causes buttock pain.
The piriformis muscle can also irritate the nearby sciatic nerve and cause pain, numbness and tingling along the back of the leg and into the foot (similar to sciatic pain).
The Piriformis Muscle
The piriformis muscle is a small muscle located deep in the buttock (behind the gluteus maximus). Continue reading
Bone pain mechanism in osteoporosis: a narrative review free full-text PMC5119722 – Clin Cases Miner Bone Metab. 2016 May-Aug
Bone pain in elderly people dramatically affects their quality of life, with osteoporosis being the leading cause of skeletal related events.
Peripheral and central mechanisms are involved in the pathogenesis of the nervous system sensitization.
Osteoporosis in the elderly has been associated with increased density of bone sensory nerve fibers and their pathological modifications, together with an over-expression of nociceptors sensitized by the lowering pH due to the osteoclastic activity. Continue reading