Tag Archives: collagen

Widespread Effects of Defective Collagen

Collagen – Wikipedia – This protein, affected by Ehlers-Danlos and other connective tissue disorders, has multiple critical roles and gives structural support throughout the whole body.

Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content.

Depending upon the degree of mineralization, collagen tissues may be rigid (bone), compliant (tendon), or have a gradient from rigid to compliant (cartilage).  Continue reading

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Fascia: A Hidden Piece of Fibromyalgia Pain

Fascia: A Hidden Piece of the Puzzle of Fibromyalgia Pain – Fibro News Daily | April 25, 2017 | By Ginevra Liptan, MD

Many studies have shown that the fibromyalgia nervous system has become sensitized and therefore has overactive responses resulting in pain.

This is the target of the three FDA approved medications for this illness, and these medications can indeed be helpful—usually resulting in about 30 percent reduction of pain.

In my experience, both as someone with the illness personally and as a physician treating fibromyalgia, utilizing these medications alone is inadequate.  Continue reading

Combating Wear and Tear on Our Collagen

Combating Wear and Tear on Our Collagen – University of Utah – Mar-2017

This article explains much of what causes our pain from EDS. With our defective collagen, even small stresses can cause “sub-failure damage” which accumulates until the tissue fails completely.

University of Utah bioengineers detect early signs of damage in connective tissues such as ligaments, tendons and cartilage

By the time someone realizes they damaged a ligament, tendon or cartilage from too much exercise or other types of physical activity, it’s too late. The tissue is stretched and torn and the person is writhing in pain.
Continue reading

Pain in Ehlers-Danlos syndromes

Pain in Ehlers-Danlos syndromes: manifestations, therapeutic strategies and future perspectives: Expert Opinion on Orphan Drugs: Vol 4, No 11 – Marco Castori  – 20 Sep 2016

Introduction: Ehlers-Danlos syndrome (EDS) groups together an increasing number of hereditary soft connective tissue disorders.

Among the most common variants, the hypermobility type emerges as the most problematic, due to

  1. clinical similarities with the joint hypermobility syndrome,
  2. strong association with pain and lack of molecular confirmatory tests.

To date, chronic pain and the related physical disability are the most relevant clinical issues in the long-term management of EDS.   Continue reading

The fascial (connective tissue) system

Clinical and symptomatological reflections: the fascial system – J Multidiscip Healthc. 2014 – free full-text PMC article

Every body structure is wrapped in connective tissue, or fascia, creating a structural continuity that gives form and function to every tissue and organ.

Currently, there is still little information on the functions and interactions between the fascial continuum and the body system; unfortunately, in medical literature there are few texts explaining how fascial stasis or altered movement of the various connective layers can generate a clinical problem

Certainly, the fascia plays a significant role in conveying mechanical tension, in order to control an inflammatory environment.   Continue reading

Revitalizing Aging Collagen with Topical Vitamin C

Revitalizing Aging Skin with Topical Vitamin C – Life Extension

I found this article interesting and relevant because the faulty collagen in our skin due to EDS causes our skin to degrade much quicker. It’s also an interesting description of how this antioxidant biochemically affects collagen production.

Overexposure to ultraviolet radiation and environmental pollutants can accelerate skin aging by degrading collagen and triggering oxidative stress in the skin

Vitamin C is an essential component in the body’s production of collagen and a potent antioxidant that can help rejuvenate aged and photodamaged skin.   Continue reading

Newly discovered features of collagen

Media Availability: Newly discovered features of collagen may help shed light on disease processes – NHLBI, NIH – July 12, 2016

Scientists at the National Institutes of Health are reporting new, unexpected details about the fundamental structure of collagen, the most abundant protein in the human body.

In lab experiments, they demonstrated that collagen, once viewed as inert, forms structures that regulate how certain enzymes break down and remodel body tissue.

The finding of this regulatory system provides a molecular view of the potential role of physical forces at work in heart disease, cancer, arthritis, and other disease-related processes, they say.   Continue reading

The Science of Stretch

The Science of Stretch | The Scientist Magazine®

It joins your thigh to your calf; your hand to your arm; your breastbone to your clavicle. As you move, it allows your muscles to glide past one another. It acts like a net suspending your organs and a high-tech adhesive holding your cells in place while relaying messages between them.

Connective tissue is one of the most integral components of the human machine. Indeed, one could draw a line between any two points of the body via a path of connective tissue.

This network is so extensive and ubiquitous that if we were to lose every organ, muscle, bone, nerve, and blood vessel in our bodies, we would still maintain the same shape: our “connective-tissue body.”   Continue reading

Myofascial Elements of Low Back Pain

Myofascial Elements of Low Back Pain

This article has some excellent Figures showing various postures and musculature.

When treating myofascial trigger points (TrPs), contributing musculoskeletal, posture, and motion factors must be addressed in order to optimize outcomes.

Etiologies of Chronic Low Back Pain

While herniated disc, spinal stenosis, spondylosis, and facet arthropathy are often considered along with myofascial origins, myofascial trigger points (TrPs) have been shown as coexisting with the other commonly accepted causes.   Continue reading