- Biosynthesis of collagen
- Types and functions of collagen
- Degradation and remodeling of collagen
- Biomedical applications
- Collagen in periodontal tissue
- Collagen disorders
Connective tissue is a fibrous cell-sparse network that helps to connect, support, bind, and separate neighboring tissues from one another.
It exists in and around every organ of the body.
Probably the most recognizable forms of connective tissue are bones (calcified), tendons, ligaments, cartilage, and fats. One major component of connective tissue is the extracellular matrix (ECM), which is composed of various molecules (e.g., proteins) that give structural and communicative support to nearby cells. Continue reading
The thoracolumbar fascia: anatomy, function and clinical considerations – free full-text /PMC3512278/ – J Anat. – 2012 May 27.
In this overview, new and existent material on the organization and composition of the thoracolumbar fascia (TLF) will be evaluated in respect to its anatomy, innervation biomechanics and clinical relevance.
The integration of the passive connective tissues of the TLF and active muscular structures surrounding this structure are discussed, and the relevance of their mutual interactions in relation to low back and pelvic pain reviewed.
The TLF is a girdling structure consisting of several aponeurotic and fascial layers that separates the paraspinal muscles from the muscles of the posterior abdominal wall. Continue reading
Living with Ehlers-Danlos Syndrome – Reviewed by Susha Cheriyedath, MSc – Oct 26, 2017
Ehlers-Danlos Syndrome, in short, EDS refers to a bunch of hereditary connective tissue disorders.
Connective tissues are a complex mixture of proteins and other substances that provide strength and elasticity to the underlying structures in the human body. Continue reading
Collagen – Wikipedia – This protein, affected by Ehlers-Danlos and other connective tissue disorders, has multiple critical roles and gives structural support throughout the whole body.
Depending upon the degree of mineralization, collagen tissues may be rigid (bone), compliant (tendon), or have a gradient from rigid to compliant (cartilage). Continue reading
Fascia: A Hidden Piece of the Puzzle of Fibromyalgia Pain – Fibro News Daily | April 25, 2017 | By Ginevra Liptan, MD
Many studies have shown that the fibromyalgia nervous system has become sensitized and therefore has overactive responses resulting in pain.
This is the target of the three FDA approved medications for this illness, and these medications can indeed be helpful—usually resulting in about 30 percent reduction of pain.
In my experience, both as someone with the illness personally and as a physician treating fibromyalgia, utilizing these medications alone is inadequate. Continue reading
Combating Wear and Tear on Our Collagen – University of Utah – Mar-2017
This article explains much of what causes our pain from EDS. With our defective collagen, even small stresses can cause “sub-failure damage” which accumulates until the tissue fails completely.
University of Utah bioengineers detect early signs of damage in connective tissues such as ligaments, tendons and cartilage
By the time someone realizes they damaged a ligament, tendon or cartilage from too much exercise or other types of physical activity, it’s too late. The tissue is stretched and torn and the person is writhing in pain.
Introduction: Ehlers-Danlos syndrome (EDS) groups together an increasing number of hereditary soft connective tissue disorders.
Among the most common variants, the hypermobility type emerges as the most problematic, due to
- clinical similarities with the joint hypermobility syndrome,
- strong association with pain and lack of molecular confirmatory tests.
To date, chronic pain and the related physical disability are the most relevant clinical issues in the long-term management of EDS. Continue reading
Clinical and symptomatological reflections: the fascial system – J Multidiscip Healthc. 2014 – free full-text PMC article
Every body structure is wrapped in connective tissue, or fascia, creating a structural continuity that gives form and function to every tissue and organ.
Currently, there is still little information on the functions and interactions between the fascial continuum and the body system; unfortunately, in medical literature there are few texts explaining how fascial stasis or altered movement of the various connective layers can generate a clinical problem
Certainly, the fascia plays a significant role in conveying mechanical tension, in order to control an inflammatory environment. Continue reading
I found this article interesting and relevant because the faulty collagen in our skin due to EDS causes our skin to degrade much quicker. It’s also an interesting description of how this antioxidant biochemically affects collagen production.
Overexposure to ultraviolet radiation and environmental pollutants can accelerate skin aging by degrading collagen and triggering oxidative stress in the skin
Vitamin C is an essential component in the body’s production of collagen and a potent antioxidant that can help rejuvenate aged and photodamaged skin. Continue reading