Tag Archives: depression

Ketamine for Pain Management, Treatment of Depression

Ketamine for Pain Management, Treatment of DepressionLinda Peckel – May 30, 2017

Ketamine may alleviate depression, pain, and side effects associated with opioid treatment, and may thus represent an attractive adjunct therapy for pain management, according to a novel population analysis recently published in Scientific Reports.

Nearly half of all patients with depression taking conventional antidepressants discontinue their treatment prematurely.

 Researchers have sought alternatives to standard antidepressants, for which therapeutic effects are delayed by 2 to 10 weeks.   Continue reading

One-Time Injection That Can Treat Depression

The One-Time Injection That Treats Depression – PsyBlog – undated, on after 2014

A single botox injection has been found to substantially improve depressive symptoms, research finds.

Botox is typically used to decrease the appearance of wrinkles in the face.

But, researchers have found that it can also help to treat the symptoms of depression.

For the study, 74 depressed people were given an injection to the facial muscles between the eyebrows — those related to frowning.  Continue reading

Metacognitive Therapy for Depression

Frontiers | Metacognitive Therapy for Depression in Adults: A Waiting List Randomized Controlled Trial with Six Months Follow-Up | Psychology for Clinical Settings – January 2017

This small study (39 patients) shows this type of therapy is effective for depression.

This randomized controlled trial examines the efficacy of metacognitive therapy (MCT) for depression.

Participants receiving MCT improved significantly more than the WL group.   Continue reading

Interaction of antidepressants and body’s opioid system

Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects–a possible opioid involvement in severe depression – PubMed – NCBI – J Mol Neurosci. 2002 Feb

This is an interesting look at the interaction of antidepressants and our body’s opioid system. It proposes that the body’s opioid system is involved in severe depression.

The efficacy of each antidepressant available has been found equal to that of amitriptyline in double-blind studies as far as mild to moderate depression is involved.   Continue reading

Hormone treatment of depression

Hormone treatment of depression – NCBI – Dialogues Clin Neurosci. 2011 Mar – free fulll-text PMC article

Disorders of the thyroid axis have been closely linked to psychiatric disorders.  While hyperthyroidism may present with a heterogenous range of psychiatric symptoms and syndromes, clinical hypothyroidism is invariably associated with depressive symptoms.

Although extensive research has shown that the vast majority of patients who present with major depression are euthyroid [normal thyroid], the close association between depression and hypothyroidism led to a large database of studies in which various hormones of the thyroid axis have been used to treat depression as monotherapy or, more commonly, as adjunct to standard antidepressants.

Each of the hormones of the thyroid axis will be reviewed.  Continue reading

Overview of Depression Mgmt during Pain

Depression Management during the Presence of Pain: An Overview – January 20, 2015 – free full text article

Depression and anxiety are frequently associated with increased risk of medical problems. The severity of these problems varies from persistent pain to severe cardiovascular illness.

The pathophysiology of chronic pain and depression overlap in the noradrenergic and serotonergic pathways.

Antidepressants, especially dual acting which affect both pathways, are a frequent and effective choice of treatment for chronic pain.

The effectiveness of antidepressants for pain has not been proven and many pain patients get zero relief from them, including me.n Continue reading

The Link Between Opioids and Unemployment

The Link Between Opioids and Unemployment –  OLGA KHAZAN – Apr 18, 2017

Since 1990, drug overdose deaths have increased by 500 percent.

A new study suggests unemployment might be one of the factors behind that dramatic rise. The paper, published by NBER last week, finds that:

As the unemployment rate increases by one percentage point in a given county,

  • the opioid-death-rate rises by 3.6 percent, and 
  • emergency room visits rise by 7 percent.  

Continue reading

Depression rates rise 18 percent in a decade

‘Let’s Talk’, WHO says, as depression rates rise 18 percent in a decade| Reuters – Mar 30, 2017 – By Kate Kelland

Depression is now the leading cause of ill health and disability worldwide, the World Health Organization (WHO) said on Thursday, with more than 300 million people suffering.

Rates of depression have risen by
more than 18 percent since 2005

WHO expressed concern that in many countries there is little or no support for people with mental health disorders, and said only around half of people with depression get treatment in wealthier nations.

On average just 3 percent of government health budgets is spent on mental health, varying from less than 1 percent in poor countries to 5 percent in rich ones, according to the WHO.

 

Borderline Personality Disorder: Shortage of Endogenous Opioids?

Borderline Personality Disorder: A Dysregulation of the Endogenous Opioid System?Psychological ReviewResearchGate – April 2010 – free PDF Download Available

The neurobiology of borderline personality disorder (BPD) remains unclear. Dysfunctions of several neurobiological systems, including serotoninergic, dopaminergic, and other neurotransmitter systems, have been discussed.

Here we present a theory that alterations in the sensitivity of opioid receptors or the availability of endogenous opioids constitute part of the underlying pathophysiology of BPD.

This is a radical idea, but I’ve read it before: certain psychological states in certain people can be relieved by opioids. However, even if this proves to be true, we certainly won’t be prescribed this particular drug, no matter how effective it is at easing mental disorders since it’s not even being used for physical pain anymore.  Continue reading

N-acetylcysteine (NAC) for inflammation

I stumbled upon this first article pointing out the various possible benefits of the supplement, N-acetylcysteine (NAC), because it reduces inflammation. This made me curious, so I checked for studies of it in PubMed (2 of which are annotated later in this post) and found the article was correct in its assertions.

Problems? I Have a NAC for That | Psychology Today

NAC is not only the treatment for mucus build-up in cystic fibrosis, but also acetaminophen overdose, perhaps to reduce the kidney toxicity of contrast dye (though that doesn’t seem to be holding up), in interstitial lung disease, and investigationally in reduction of noise-induced hearing loss, lessening the destruction of pancreatic beta cells, curing a hangover, and decreasing symptoms of the flu.   Continue reading