Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms – Br J Psychiatry. 2012 Jun – free full text /PMC3365276/
This is not a new article, but a thorough scientific survey of the brain differences seen in people with hypermobility (which is usually undiagnosed EDS). This was the beginning of my understanding that EDS is not just a physical issue, but also affects our minds.
To me, it makes sense that the same instability (lack of balance, tendency to extremes) found in our bodies would also be represented in our brains/minds.
Joint hypermobility is overrepresented among people with anxiety and can be associated with abnormal autonomic reactivity. Continue reading
The Unaddressed Casualty Of The War On Opiates – We are patients not addicts – Kaitlyn Brennan – Aug 22, 2016
War is always depicted as a two sided battle. Often it is written off as the good guys against the bad guys, whom you choose to put into each category is up to you, but there are always two sides.
The side that no one sees is the third side of a war. This is the side that is often overlooked or considered insignificant.
In the war on opiates this third side is chronic pain patients. Continue reading
Chronic, Noncancer Pain Boosts Suicide Risk – Fran Lowry – May 28, 2013
Though a bit older, this study found that pain is an important predictor of suicide risk – especially when it is diagnosed as “psychogenic pain”.
Previous research suggests that individuals with pain may be at increased risk for suicidal thoughts and behaviors, but it is likely that “not all pain is created equal” in terms of its association with suicide, and that the association between pain and suicide could vary, depending on the type of pain patients experience, Dr. Ilgen said.
The study was published online May 22, 2013 in JAMA Psychiatry. In the current study, the investigators sought to understand the degree to which specific pain conditions related to suicide risk. Continue reading
Hypermobility, the Ehlers-Danlos syndromes and chronic pain – D. Syx, I. De Wandele, L. Rombaut, F. Malfait – Clin Exp Rheumatol – Sept 2017
This research article explains why EDS leads to chronic pain and urges doctors to treat whatever pain symptoms arise because there is no possible cure or even slowing down of the degenerative process.
Chronic widespread pain is a common complaint among individuals affected by generalised joint hypermobility. In the absence of other conditions that cause chronic pain, these individuals are usually diagnosed with joint hypermobility syndrome (JHS).
JHS is a multifactorial trait with a strong genetic basis, but no specific genetic markers. Clinical overlap of JHS is seen with heritable connective tissue disorders, particularly with the Ehlers-Danlos syndrome, hypermobile type (hEDS). Continue reading
Generalized Hyperalgesia in Children and Adults Diagnosed With Hypermobility Syndrome and Ehlers‐Danlos Syndrome Hypermobility Type: A Discriminative Analysis – Scheper – 2017 – Arthritis Care & Research – Wiley Online Library – Pediatric Rheumatology – Free Access – August 2016
The phenotypes of hypermobility syndrome (HMS) and Ehlers‐Danlos syndrome hypermobility type (EDS‐HT) are characterized by generalized connective tissue laxity and connective tissue fragility.
Due to the compromised structural integrity of connective tissue, individuals with HMS/EDS‐HT are assumed to be more prone to injury and consequent disability.
Yes, the above sums up the situation with EDS perfectly. Continue reading
Below are three PubMed studies from 2015 about the detrimental effects of EDS on the mind/brain:
Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry. – PubMed – NCBI – Gen Hosp Psychiatry. 2015 Jan-Feb
OBJECTIVE: The heritable disorders of connective tissue (HDCTs) are a group of genetic disorders affecting connective tissue matrix proteins. Continue reading
Below are 4 articles from PubMed that show EDS is associated with anxiety, depression, and other disorders of the central nervous system, like fibromyalgia and irritable bowel syndrome.
Connective tissue is *everywhere* in our bodies (yes, including our bones), so the defects in our body tissues extend to the brain as well.
I’ve been plagued by periods of desperate anxiety for the last decade and periods of suicidal depression for all my adult life, so I’m not surprised that the instability and slackness of our bodies are also manifested in our psychology. My moods never feel stable and can easily be derailed.
The number of possible EDS symptoms seems infinite… Continue reading
Does The Rare Disease EDS Plague Fibromyalgia? – February 23, 2018 – By Celeste Cooper
hEDS = EDS hypermobile type, previously known as EDS type III or joint hypermobility syndrome.
According to the National Organization for Rare Disorders (NORD), there are many Ehlers Danlos Syndromes and related disorders caused by different genetic defects in collagen. We will focus on the most common type of Ehlers-Danlos syndrome in this article.
this type of EDS can co-occur in fibromyalgia and myofascial pain syndrome even though it is thought to be a rare condition. Fibromyalgia and EDS also share connections you might not have considered. Continue reading
Ehlers-Danlos Syndrome in Orthopaedics: Etiology, Diagnosis, and Treatment Implications – Sep 2012 – free full-text /PMC3435946/
Ehlers-Danlos syndrome is a
- heterogeneous connective tissue condition
characterized by varying degrees of
- skin hyperextensibility,
- joint hypermobility, and
- vascular fragility.
Study Title: Use of Complementary Therapies for Pain Management in Patients with Ehlers-Danlos and Hypermobility Spectrum Disorders – Principal Investigator: Jessica Demes
The purpose of our study is to learn more about how adult patients manage their pain when affected by Ehlers Danlos or a Hypermobility Spectrum Disorder. We are hoping that you could provide your opinions and perspectives in this survey.
To join the study, we will ask you to complete a survey with questions about hypermobility and how you experience and manage any pain you have. These questions may take approximately 30-45 minutes to complete.