Tag Archives: fatigue

Toward a better understanding of fatigue in chronic pain

Tired of pain? Toward a better understanding of fatigue in chronic pain : PAIN

Fatigue is a prevalent complaint in people with chronic pain.

A study in the general population showed that 64% of the individuals with chronic widespread pain reported co-occurring persistent fatigue. In patients with chronic pain due to spinal cord injury, 70% reported persistent fatigue.

Such comorbid fatigue is likely to be an additional source of disability and suffering when left untreated.   Continue reading

Quality of Life in Joint Hypermobility Syndrome/EDS

Systemic Manifestations and Health-Related Quality of Life in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome-Hypermobility Type – Sydney Medical School, Discipline of Biomedical Science – Krahe, Anne 

Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome-Hypermobility Type (JHS/EDS-HT) is a hereditary connective tissue disorder associated with both musculoskeletal and systemic manifestations.

There is increasing recognition of the significance of the non-musculoskeletal manifestations of the disorder, such as

  • fatigue,
  • orthostatic intolerance,
  • gastrointestinal symptoms and
  • psychological features, Continue reading

Chronic Pain is Exhausting: Fatigue Severity Scale

I found this fatigue scale during my research and felt it applies to any patient who lives with constant pain.

Chronic pain is exhausting.

Even if we are ignoring it mentally, our bodies have to cope with the constant stimulation of pain signals from nociception and inflammation. These biological activities come with a cost: depleted energy.

This “Fatigue Severity Scale” is used to measure the fatigue caused by Lyme disease, Chronic Fatigue Syndrome, Lupus, multiple sclerosis, and rheumatoid arthritis – why not EDS as well? Continue reading

Chronic fatigue in EDS Hypermobile type

Chronic fatigue in Ehlers–Danlos syndrome—Hypermobile typeHakim – 2017 – American Journal of Medical Genetics Part C: Seminars in Medical Genetics – Wiley Online Library


It is the authors’ opinion that the criteria used for diagnosing CFS and hEDS are inadequate and contribute to diagnostic confusion.

To meet a diagnosis of CFS, fatigue must be “unexplained by other conditions.”

Therefore, a diagnosis of hEDS must exclude a diagnosis of CFS.

However, hEDS is likely to be substantially under-diagnosed and it is likely that some patients diagnosed with CFS may meet or would previously have met the criteria for diagnosis of hEDS.   Continue reading

All Fatigue is Not Created Equal

All Fatigue is Not Created Equal: Why it Matters and What it Means for Pain Management – by  Ian Boggero – April 6, 2017

For people with chronic pain conditions, feelings of fatigue may be the norm rather than the exception. In fact, fatigue is one of the most common symptoms reported by patients with chronic pain and increases as the intensity of the pain increases.

Why does fatigue matter? It predicts low quality of life and poor functioning in a number of chronic pain populations, including cancer and lower back pain.

In our work, we found that fatigue predicts low satisfaction with life in patients with chronic orofacial pain (pain in the head and face), and partially explains why pain is associated with psychological distress.   Continue reading

Autonomic Dysfunction and Fatigue in hEDS

Excellent information on EDS in general, from a slideshow by Alan Pocinki, MD (I can’t find the original link):

Autonomic Dysfunction and Fatigue

Cardio Vascular Dysregulation

  • POTS- Postural Tachycardia Syndrome
  • OH- Orthostatic Hypotension
  • NMH- Neurally mediated hypotension (vaso-vagal syncope, neuro-cardiogenic syncope, delayed orthostatic hypotension)
  • OI- Orthostatic Intolerance

What We Know About Cardiovascular Dysregulation   Continue reading

Mitochondrial Dysfunction and Post-Exertional Malaise

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME

Though this article refers to Chronic Fatigue Syndrome, these symptoms often overlap with other chronic conditions, like Fibromyalgia.  Also, people with EDS are often suspected of having mitochondrial issues.

It has been well documented that there is an abnormal increase in cytokines (chemicals released by the immune system) in CFS/ME patients following mild exercise. This causes another type of fatigue on top of the mitochondrial dysfunction fatigue discussed below. Cytokines in general, without the exercise trigger, can cause fatigue.  There are probably additional causes of fatigue (such as orthostatic intolerance) as well.

Role of mitochondria in cellular function

Continue reading

Fatigue in chronic inflammation – a link to pain pathways

Fatigue in chronic inflammation – a link to pain pathways | 2015 Oct | Full-text PMC article

This is a long, detailed, technical article about the link between fatigue, pain, and inflammation.

Fatigue is a frequent symptom in several inflammatory diseases, particularly in rheumatic diseases. Elements of disease activity and cognitive and behavior aspects have been reported as causes of fatigue in patients with rheumatoid arthritis.

Fatigue could be associated with activity of inflammatory rheumatism. Indeed, biologic agents targeting inflammatory cytokines are effective in fatigue.   Continue reading

Management of pain and fatigue in EDS

Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach. – PubMed – NCBI | Am J Med Genet A. 2012 Aug

Here is more proof that EDS causes pain and fatigue, which requires treatment and has a severe impact on our quality of life.

Joint hypermobility syndrome (JHS), or Ehlers-Danlos syndrome (EDS) hypermobility type (EDS-HT), is a underdiagnosed heritable connective tissue disorder characterized by generalized joint hypermobility and a wide range of visceral, pelvic, neurologic, and cognitive dysfunctions.

Deterioration of quality of life is mainly associated with pain and fatigue.   Continue reading

Comorbidities of EDS

Comorbidities of EDS | Oh Twist!

As I’ve mentiond numerous times throughout this blog, people with Ehlers-Danlos Syndrome seriously win the bad health lottery when it comes to comorbidities, or conditions you have along with a primary condition.

I think it helps when you remember that collagen runs through 80% of the body, so affects virtually every system.

Lastly, I’ll note that there are often BOTH bio-mechanical (physical, e.g. impinged nerves, muscle tension, herniations, loose ligaments), and bio-chemical (e.g. allergy, MCAD) causes to many of our issues (e.g. headaches, frequent urination) lending to the diagnostic and treatment challenge.   Continue reading