Stress Hormone Causes Epigenetic Changes | National Institutes of Health (NIH) – September 27, 2010
Researchers found that chronic exposure to a stress hormone causes modifications to DNA in the brains of mice, prompting changes in gene expression. The new finding provides clues into how chronic stress might affect human behavior.
And how about the chronic stress from living with constant pain? And never being able to plan ahead because it’s impossible to know how much pain any day or time will bring, impossible to know what you’ll be capable of at any specific time?
What about the stress of being disabled from earning a paycheck and making a living, of having to rely on government handouts and the generosity of family and friends?
And, to top it off, always having to worry whether your doctor will continue prescribing opioids or leave you to suffer the endless torture without relief? Continue reading
Patients with Arachnoiditis and Ehlers-Danlos Need Adrenaline for Pain Control — Pain News Network – By Dr. Forest Tennant, PNN Columnist – Feb 2020
In this era of opioid controversy and tragedy due to forced opioid reduction, the scientific information on adrenaline-type agents can help control constant, intractable pain and help reduce opioid use.
Overlooked in the opioid controversy is the key point that an adequate supply of adrenaline-related neurotransmitters – such as dopamine and norepinephrine – are necessary in the brain and spinal cord for pain relief.
Unfortunately, constant intractable pain depletes the natural supply of endorphin, dopamine, adrenaline and noradrenalin, and their levels must be replaced to adequately control pain.
This is just a small part of the damage wrought by our chronic pain andyou can find many more posts here itemizing all the ways that untreated pain ravages a body. Continue reading
Effect of Estrogen on Musculoskeletal Performance and Injury Risk – free full-text /PMC6341375/ – Jan 2019
Estrogen has a dramatic effect on musculoskeletal function.
Beyond the known relationship between estrogen and bone, it directly affects the structure and function of other musculoskeletal tissues such as muscle, tendon, and ligament. In these other musculoskeletal tissues, estrogen improves muscle mass and strength, and increases the collagen content of connective tissues.
However, unlike bone and muscle where estrogen improves function, in tendons and ligaments estrogen decreases stiffness, and this directly affects performance and injury rates.
This can be important for those of us with EDS or HMS (or perhaps some other connective tissue problem) because it affects tendon & ligament function by decreasing stiffness. Continue reading
The role of genetics in estrogen responses: a critical piece of an intricate puzzle – free full-text article /PMC4232287/ – Dec 2014
The estrogens are female sex hormones that are involved in a variety of physiological processes, including reproductive development and function, wound healing, and bone growth.
In addition to the role of estrogens in promoting tissue growth and development during normal physiological states, they have a well-established role in determining susceptibility to disease, particularly cancer, in reproductive tissues.
As with so many other biochemical components at work in our bodies, estrogen has both positive and negative effects and we each react differently depending on how the rest of our body is built. Continue reading
Here are 3 studies on how estrogen can prevent muscle wasting and improve mitochondrial function.
Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength. – PubMed – NCBI – Jun 2019
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss of estrogen with ovarian failure.
Estrogen deficiency mediates decrements in muscle strength from both
- inadequate preservation of skeletal muscle mass and
- decrements in the quality of the remaining skeletal muscle.
Here are 4 PubMed scientific studies exploring how estrogen affects all different aspects of pain: its sensation, its interaction with opioid receptors, and its memory. Estrogen is clearly important, but the interactions with pain sensation are very complex.
Just like with hormone replacement therapy, the effects of estrogen on pain probably differ a great deal between individuals.
Pronociceptive and Antinociceptive Effects of Estradiol through Endogenous Opioid Neurotransmission in Women – NCBI – May 2006
Prominent interindividual and sex-dependent differences have been described in responses to sustained pain and other stressful stimuli. Variations in μ-opioid receptor-mediated endogenous opioid neurotransmission may underlie some of these processes. Continue reading
Physical Activity and Brain Health – free full-text PMC6770965/ – Genes (Basel). Sep 2019 – continued from Part 1
Exercise-Dependent Production of Dopamine, Endocannabinoids, and Opioids: Effects on Mood, Analgesia, and Happiness
In addition to an improvement of body fitness and learning and memory skills, it is well documented that PA (Physical Activity) can induce changes in the mental status, reducing anxiety and producing a general sense of wellbeing.
Moreover, it can induce analgesia.
Really? When I engage in physical activity, it’s usually a painful endeavor. If I didn’t enjoy some activities so very much, like hiking, bicycling, and dancing, I can’t imagine I’d have the will to do them.
Physical Activity and Brain Health – free full-text PMC6770965/ – Genes (Basel). Sep 2019
Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. However, only recently the health consequences of a sedentary lifestyle, and of highly energetic diets, are becoming clear.
It has been also acknowledged that lifestyle and diet can induce epigenetic modifications which modify chromatin structure and gene expression, thus causing even heritable metabolic outcomes.
About 50 years ago, scientists first learned that genetics has another layer, epigenetics. It matters not just what your genes are, but also on whether they are turned on or off. Continue reading
Because fascia is made from collagen, the genetic defect from EDS will often cause us problems with this tissue. It’s thin, fragile, stretches too much, and gives way too easily.
PubMed Central® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health’s National Library of Medicine (NIH/NLM).
Research on the body’s fascia (connective tissue) is finding more and more of its functions and abilities, going far beyond just “holding stuff together”. I’ve posted here the abstracts of the following 4 articles and you can decide for yourself if they’re worth reading in full.
- Smooth Muscle
- Visceral Fascia
- Bone Tissue
- Hormone Receptor Expression in Human Fascial Tissue
Total serum testosterone and WOMAC pain and function among older men and women with severe knee OA – Freystaetter – – Arthritis Care & Research – Wiley Online Library – Sep 2019
I’m just showing the abstract here, but a watermarked pre-publication version of the full article is available at: https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.24074
We investigated if serum total testosterone (T)‐level is associated with knee pain and function in men and women with severe knee osteoarthritis (OA). Continue reading