Tag Archives: hormones

Hormone abnormalities from severe chronic pain

Hormone abnormalities in patients with severe and chronic pain who fail standard treatments. – PubMed – NCBI – Dec 2014

Some patients with severe and chronic pain fail to obtain adequate pain relief with standard pharmacologic treatment agents, including low to moderate dosages of opioids.

Understandably, physicians might not believe patients who claim that a standard opioid dosage is an ineffective treatment. These patients may be severely impaired, nonfunctional, and bedridden or housebound

To help characterize these individuals and develop treatment strategies for them, a serum hormone profile consisting of   Continue reading


Ehlers-Danlos Syndrome: A Challenge for Pain Management

Ehlers-Danlos Syndrome: An Emerging Challenge for Pain Management – Editor’s Memo—September 2017 – By Forest Tennant, MD, DrPH

Thank you, Dr. Tenant, for drawing attention to this terribly painful genetic syndrome that is completely ignored by so many pain specialists, even as it clearly causes increasing physical pain.

Until recently, Ehlers-Danlos Syndrome (EDS) was a name that elicited little relevance or urgency in the pain world.

Little did I realize that I had been treating more cases of EDS in patients who had been referred to my practice initially for more commonly recognized diagnoses such as fibromyalgia, spine degeneration, and resistant migraine.   Continue reading

Testosterone to treat central sensitization

A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients – ScienceDirect – August 2015


  • Testosterone is effective therapy for fibromyalgia.
  • Low/deficient testosterone levels are linked to a high risk for chronic pain states.
  • Novel mechanisms by which testosterone is likely to down-modulate pain signals
  • Mechanisms involving testosterone are linked to central sensitization.

Continue reading

Hormones affect connective tissues

Alterations to cell metabolism in connective tissues of the knee after ovariohysterectomy in a rabbit model: are there implications for the postmenopausal athelete? – PubMed – NCBI Br J Sports Med. 2010 Sep;

Participation in regular exercise and athletic activities across the lifespan is encouraged to maintain the cardiovascular and musculoskeletal systems and general wellbeing.

Before the menopause there is an increased risk of anterior cruciate ligament (ACL) injuries in female athletes, whereas there is an increased risk of joint diseases such as knee osteoarthritis after the menopause.

Although there are few data regarding alterations in individual connective tissues of the knee in humans either before, during or after the menopause, it is possible to assess changes in experimental models following surgical menopause.   Continue reading

Hormone treatment of depression

Hormone treatment of depression – NCBI – Dialogues Clin Neurosci. 2011 Mar – free fulll-text PMC article

Disorders of the thyroid axis have been closely linked to psychiatric disorders.  While hyperthyroidism may present with a heterogenous range of psychiatric symptoms and syndromes, clinical hypothyroidism is invariably associated with depressive symptoms.

Although extensive research has shown that the vast majority of patients who present with major depression are euthyroid [normal thyroid], the close association between depression and hypothyroidism led to a large database of studies in which various hormones of the thyroid axis have been used to treat depression as monotherapy or, more commonly, as adjunct to standard antidepressants.

Each of the hormones of the thyroid axis will be reviewed.  Continue reading

Hormones & Hypermobility

Hypermobility Syndromes Association » Hormones & Hypermobility – By Alan Hakim, June 9, 2013

A hormone is sometimes described as a ‘chemical messenger’ that is secreted from a gland, circulates through the bloodstream and, finally, reaches the organ at which it is directed where it exerts its effect.  

Although there are many types of hormones, all of different structures, two main groups are relevant to hypermobility.

Firstly are the corticosteroids, which comprise three families:  Continue reading

The Physiologic Effects of Pain on Hormones

The Physiologic Effects of Pain on the Endocrine System – Pain Ther. – by Forest Tennant – 2013 Dec – free full-text PMC article

Severe pain has profound physiologic effects on the endocrine system.

Serum hormone abnormalities may result and these serve as biomarkers for the presence of severe pain and the need to replace hormones to achieve pain control.

Initially, severe pain causes a hyperarousal of the hypothalamic–pituitary–adrenal system which results in elevated serum hormone levels such as adrenocorticotropin, cortisol, and pregnenolone.  Continue reading

Guidelines for the Treatment of Hypothyroidism

Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement – 2014 Dec – free full-text PMC article

related to The Fibromyalgia-Thyroid Connection

Background: A number of recent advances in our understanding of thyroid physiology may shed light on why some patients feel unwell while taking levothyroxine monotherapy

The purpose of this task force was to review

  • the goals of levothyroxine therapy,
  • the optimal prescription of conventional levothyroxine therapy,
  • the sources of dissatisfaction with levothyroxine therapy,
  • the evidence on treatment alternatives, and
  • the relevant knowledge gaps.

This document is intended to inform clinical decision-making on thyroid hormone replacement therapy; it is not a replacement for individualized clinical judgment.  Continue reading

Pain & Fatigue from Subclinical Hypothyroidism

Subclinical hypothyroidism: summary of evidence in 2014 – Swiss Med Wkly. 2014 – free full-text

Because the symptoms of low thyroid overlap with those of Fibromyalgia and EDS (see The Fibromyalgia-Thyroid Connection), it may be worth checking thyroid levels to see if this might be contributing to the severity of symptoms.

My thyroid tests were on the low side of “normal”, but I’m blessed with a wonderful doctor who let me try supplementing with Armour thyroid based on my symptoms, not just my numbers.

Within days, I felt some relief from the worst of the heavy achiness, dull fatigue, and mental stupor I’d been plagued by. Even better – and unexpectedly – it also lifted my depression.   Continue reading

The Fibromyalgia-Thyroid Connection

The Fibromyalgia-Thyroid Connection. If your TSH thyroid test is normal, you better read this… – National Pain Report – By Donna Gregory Burch – April 4, 2017

Did you know that thyroid conditions are routinely misdiagnosed as fibromyalgia?

I’m sure most of our doctors ran a TSH test to check our thyroid function since hypothyroidism is one of the many conditions that are supposed to be ruled out before diagnosing fibromyalgia.

That’s because the TSH test, the test most commonly used by doctors to diagnose thyroid issues, is a poor indicator of overall thyroid health.

It takes a much more comprehensive approach to testing and clinical expertise to properly diagnose thyroid disorders.  Continue reading