Tag Archives: hormones

Opioid Alternative, Oxytocin, for Chronic Pain

Oxytocin, an Opioid Alternative, Ready for Regular Clinical Use to Manage Chronic Pain – 

Editor’s Memo November 2017:  Dr. Tennant opens an overdue discussion on the history and future of pain medication alternatives.

…the pharmacologic properties of almost all of the currently available analgesics were established and clinically implemented more than a century ago.

Yet, a safe and effective option with a unique pharmacologic mechanism that has been right in front of us — oxytocin — has emerged as an excellent pain reliever.   Continue reading

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Hormones & Hypermobility

Hypermobility Syndromes Association » Hormones & Hypermobility – By Alan Hakim, Updated August 2017.

Which hormones are involved?

A hormone is sometimes described as a ‘chemical messenger’ that is secreted from a gland, circulates through the bloodstream and, finally, reaches the organ at which it is directed where it exerts its effect.  

Although there are many types of hormones, all of different structures, two main groups are relevant to hypermobility.   Continue reading

Physiologic Effects of Pain on the Endocrine System

The Physiologic Effects of Pain on the Endocrine System – Free full-text PMC4107914 – Pain Ther. 2013 Dec – by Forest Tennant

Severe pain has profound physiologic effects on the endocrine system.

Serum hormone abnormalities may result and these serve as biomarkers for the presence of severe pain and the need to replace hormones to achieve pain control.

Initially severe pain causes a hyperarousal of the hypothalamic–pituitary–adrenal system which results in elevated serum hormone levels such as adrenocorticotropin, cortisol, and pregnenolone.

If the severe pain does not abate, however, the system cannot maintain its normal hormone production and serum levels of some hormones may drop below normal range.   Continue reading

Hormone abnormalities from severe chronic pain

Hormone abnormalities in patients with severe and chronic pain who fail standard treatments. – PubMed – NCBI – Dec 2014

Some patients with severe and chronic pain fail to obtain adequate pain relief with standard pharmacologic treatment agents, including low to moderate dosages of opioids.

Understandably, physicians might not believe patients who claim that a standard opioid dosage is an ineffective treatment. These patients may be severely impaired, nonfunctional, and bedridden or housebound

To help characterize these individuals and develop treatment strategies for them, a serum hormone profile consisting of   Continue reading

Ehlers-Danlos Syndrome: A Challenge for Pain Management

Ehlers-Danlos Syndrome: An Emerging Challenge for Pain Management – Editor’s Memo—September 2017 – By Forest Tennant, MD, DrPH

Thank you, Dr. Tenant, for drawing attention to this terribly painful genetic syndrome that is completely ignored by so many pain specialists, even as it clearly causes increasing physical pain.

Until recently, Ehlers-Danlos Syndrome (EDS) was a name that elicited little relevance or urgency in the pain world.

Little did I realize that I had been treating more cases of EDS in patients who had been referred to my practice initially for more commonly recognized diagnoses such as fibromyalgia, spine degeneration, and resistant migraine.   Continue reading

Testosterone to treat central sensitization

A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients – ScienceDirect – August 2015

Highlights

  • Testosterone is effective therapy for fibromyalgia.
  • Low/deficient testosterone levels are linked to a high risk for chronic pain states.
  • Novel mechanisms by which testosterone is likely to down-modulate pain signals
  • Mechanisms involving testosterone are linked to central sensitization.

Continue reading

Hormones affect connective tissues

Alterations to cell metabolism in connective tissues of the knee after ovariohysterectomy in a rabbit model: are there implications for the postmenopausal athelete? – PubMed – NCBI Br J Sports Med. 2010 Sep;

Participation in regular exercise and athletic activities across the lifespan is encouraged to maintain the cardiovascular and musculoskeletal systems and general wellbeing.

Before the menopause there is an increased risk of anterior cruciate ligament (ACL) injuries in female athletes, whereas there is an increased risk of joint diseases such as knee osteoarthritis after the menopause.

Although there are few data regarding alterations in individual connective tissues of the knee in humans either before, during or after the menopause, it is possible to assess changes in experimental models following surgical menopause.   Continue reading

Hormone treatment of depression

Hormone treatment of depression – NCBI – Dialogues Clin Neurosci. 2011 Mar – free fulll-text PMC article

Disorders of the thyroid axis have been closely linked to psychiatric disorders.  While hyperthyroidism may present with a heterogenous range of psychiatric symptoms and syndromes, clinical hypothyroidism is invariably associated with depressive symptoms.

Although extensive research has shown that the vast majority of patients who present with major depression are euthyroid [normal thyroid], the close association between depression and hypothyroidism led to a large database of studies in which various hormones of the thyroid axis have been used to treat depression as monotherapy or, more commonly, as adjunct to standard antidepressants.

Each of the hormones of the thyroid axis will be reviewed.  Continue reading

Hormones & Hypermobility

Hypermobility Syndromes Association » Hormones & Hypermobility – By Alan Hakim, June 9, 2013

A hormone is sometimes described as a ‘chemical messenger’ that is secreted from a gland, circulates through the bloodstream and, finally, reaches the organ at which it is directed where it exerts its effect.  

Although there are many types of hormones, all of different structures, two main groups are relevant to hypermobility.

Firstly are the corticosteroids, which comprise three families:  Continue reading

The Physiologic Effects of Pain on Hormones

The Physiologic Effects of Pain on the Endocrine System – Pain Ther. – by Forest Tennant – 2013 Dec – free full-text PMC article

Severe pain has profound physiologic effects on the endocrine system.

Serum hormone abnormalities may result and these serve as biomarkers for the presence of severe pain and the need to replace hormones to achieve pain control.

Initially, severe pain causes a hyperarousal of the hypothalamic–pituitary–adrenal system which results in elevated serum hormone levels such as adrenocorticotropin, cortisol, and pregnenolone.  Continue reading