Tag Archives: hormones

Physical Activity and Brain Health – Part 2

Physical Activity and Brain Health – free full-text PMC6770965/ – Genes (Basel).  Sep 2019 – continued from Part 1

Exercise-Dependent Production of Dopamine, Endocannabinoids, and Opioids: Effects on Mood, Analgesia, and Happiness

In addition to an improvement of body fitness and learning and memory skills, it is well documented that PA (Physical Activity) can induce changes in the mental status, reducing anxiety and producing a general sense of wellbeing.

Moreover, it can induce analgesia.

Really? When I engage in physical activity, it’s usually a painful endeavor. If I didn’t enjoy some activities so very much, like hiking, bicycling, and dancing, I can’t imagine I’d have the will to do them.
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Physical Activity and Brain Health – Part 1

Physical Activity and Brain Health – free full-text PMC6770965/ – Genes (Basel).  Sep 2019

Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. However, only recently the health consequences of a sedentary lifestyle, and of highly energetic diets, are becoming clear.

It has been also acknowledged that lifestyle and diet can induce epigenetic modifications which modify chromatin structure and gene expression, thus causing even heritable metabolic outcomes.

About 50 years ago, scientists first learned that genetics has another layer, epigenetics. It matters not just what your genes are, but also on whether they are turned on or off.  Continue reading

Fascia Research from the NIH

Because fascia is made from collagen, the genetic defect from EDS will often cause us problems with this tissue. It’s thin, fragile, stretches too much, and gives way too easily.

PubMed Central® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health’s National Library of Medicine (NIH/NLM).

Research on the body’s fascia (connective tissue) is finding more and more of its functions and abilities, going far beyond just “holding stuff together”.  I’ve posted here the abstracts of the following 4 articles and you can decide for yourself if they’re worth reading in full.

  1. Smooth Muscle
  2. Visceral Fascia
  3. Bone Tissue
  4. Hormone Receptor Expression in Human Fascial Tissue

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Testosterone for severe knee Osteoarthritis

Total serum testosterone and WOMAC pain and function among older men and women with severe knee OA – Freystaetter – – Arthritis Care & Research – Wiley Online LibrarySep 2019

I’m just showing the abstract here, but a watermarked pre-publication version of the full article is available at: https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.24074


We investigated if serum total testosterone (T)‐level is associated with knee pain and function in men and women with severe knee osteoarthritis (OA).   Continue reading

Neurosteroid Hormone Therapy for Chronic Pain

Hormone Therapy for Chronic Pain: Are Neurosteroids the Answer?By Forest Tennant, MD, DrPH, Ingrid Hollis, Lynn Kivell Ashcraft and Kris Walters – Oct 2019

What every person living with chronic pain should know about steroids, replenishment, and more.

While pain medication may provide you with you symptomatic, temporary relief so that you can function, hormone administration as part of a pain management plan can help to bring about the healing of damaged nerves and other tissues.

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No Link Between Hormone Tx and All-Cause Mortality

No Link Between Hormone Tx and All-Cause Mortality | Medpage Today – by Jeff Minerd – September 2017

This is of interest to me because I’ve been taking estrogen alone (without progesterone) for over two decades to prevent the anxiety that inevitably arises when my estrogen level falls too low (started in iatrogenic menopause).

Despite being linked with increased risk for breast cancer and stroke, hormone therapy in postmenopausal women was not associated with long-term mortality risk, data from the Women’s Health Initiative (WHI) trials showed.

In a pooled analysis of both trials, including more than 27,000 women and a cumulative 18 years of follow-up, the rate of all-cause mortality was 27.1% in the hormone therapy group and 27.6% in the placebo group.    Continue reading

Hormonal Contraception and Depression

Association of Hormonal Contraception With Depression – JAMA Network – Charlotte Wessel Skovlund, MSc1; Lina Steinrud Mørch, PhD1; Lars Vedel Kessing, MD, DMSc2; et al. – November 2016

Question:  Is use of hormonal contraception associated with treatment of depression?

Spoiler alert: the answer is a resounding “yes”.  all the patients who didn’t get antidepressants (which require a pain or depression diagnosis).

Progesterone is in all birth-control pills, yet women seeking contraception are given these pills almost routinely, and never with the warning that they could cause depression.

This could explain why women tend to be more depressed than men.

Findings:  In a nationwide prospective cohort study of more than 1 million women living in Denmark, an increased risk for first use of an antidepressant and first diagnosis of depression was found among users of different types of hormonal contraception, with the highest rates among adolescents.   Continue reading

Your brain on PMS is like your brain on alcohol

Your brain on PMS is like your brain on alcohol and depressants – By Cassie Werber December 21, 2016

Recent research into hormonal contraceptives found a clear link between them and depression.

That’s hardly surprising, the researcher says, when you consider that all hormonal contraceptives contain progesterone, and some are progesterone-only.

How and why progesterone alters moods is understudied, but there’s a growing body of research, based on the results of blood tests and brain scans, conducted by Poromaa and others. One discovery from this research is that progesterone can trigger the small, almond-shaped part of the brain called the amygdala.   Continue reading

Intractable Pain versus Chronic Pain

What is Intractable Pain and How Does it Differ From Chronic PainBy Forest Tennant, MD, DrPH, John Liu, MD and Laura Hermann, RN, FNP – Aug 2017

Protocols for a lifetime of pain management for patients suffering constant, incurable, excruciating, unrelenting pain.

Since IP [Intractable Pain] patients always have an underlying, incurable disease or condition causing IP, their clinical management is complex and may require a specialized clinical setting.

Just as renal failure or insulin-dependent diabetes require lifetime care by a cadre of specialized medical personnel, IP likewise requires similar lifetime care due to its incurable nature.   Continue reading

Advances in Hormonal Pain Care

3 Advances in Hormonal Pain Care — Pain News NetworkBy Forest Tennant, MD – Mar 2019

There are three new discoveries or innovations in hormonal pain care that I dearly love. I believe they are real trend-setters, but keep in mind that the “next big thing” may not endure.  

Hormone Derivative Treatment

There are two hormonal derivatives that, in my hands, have been extremely beneficial to sub-groups of chronic pain patients.

The first is medroxyprogesterone, which is a derivative of progesterone. In my experience, medroxyprogesterone is far more potent in treating intractable pain patients than is plain progesterone.   Continue reading