Improving the analgesic effectiveness of opioids while also reducing the adverse effects is a major goal of pain research.
One approach to this problem has been to combine drugs such as cannabinoids with opioids to determine if this might reduce the dose of opioid required to produce analgesia.
In this experiment, male nonhuman primates (rhesus macaques) were administered a range of doses of THC in combination with cumulative doses of heroin to determine if the combinations produced greater analgesia than that observed with heroin alone.
Briefly, the animals were secured in standard primate ch airs, tails were shaved, and dipped in a mixed order in three different water temperatures (40 °, 50 °, and 55 °C) until the animal rapidly withdrew his tail, or 20 seconds elapsed. Continue reading
Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain – J Pain. 2013 Feb – free full-text PMC article
Even back in 2013, research had already shown that cannabis can be effective for pain relief,.
We conducted a double-blind, placebo-controlled, crossover study evaluating the analgesic efficacy of vaporized cannabis in subjects, the majority of whom were experiencing neuropathic pain despite traditional treatment.
Thirty-nine patients with central and peripheral neuropathic pain underwent a standardized procedure for inhaling either medium dose (3.53%), low dose (1.29%), or placebo cannabis with the primary outcome being VAS pain intensity Continue reading
A new study found that while a low dose of the cannabinoid delta-9-tetrahydrocannabinol caused young mice to perform worse in learning and memory tasks, it restored age-related learning and memory decline in old mice.
However, the researchers warn than more work must be done before it can be said that the cannabis compound might reverse cognitive decline in elderly humans
Cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are a class of more than 100 psychoactive, or mind-altering, compounds that are found in the cannabis, or marijuana, plant. They exert a powerful effect because they interact with cannabinoid receptors in the brain. Continue reading
This is the gold standard for scientific studies and it shows that THC concentrations in urine or saliva cannot determine plasma THC levels which could indicate the level of inebriation from cannabis.
Purpose. A randomized cross-over, double blind placebo controlled study of smoked cannabis was carried out on occasional cannabis smokers.
Conclusion. Prediction of plasma THC concentration from THC oral fluid concentration or from THC-COOH urinary concentrations is not feasible due to the large variations observed.
Edibles are a great option to administer medicine, but it’s important to know that the body responds differently to each mode of administration.
Consider these factors when taking edibles as opposed to smoking cannabis:
1) The effects of ingesting a cannabis infused edible takes longer to begin,
2) The effects can be stronger and more intense, and, 3) The effects can last longer.
The differences derive from how the body responds to cannabis when it is smoked as opposed to when it is ingested as an edible. Continue reading
In this paper, it’s clear the researchers are desperately trying to reach negative conclusions, even if they must resort to stating only that they “have found limited evidence to suggest that…”.
This sentence wording associates the word “evidence” with the various impairments they then list that may or may not be associated with cannabis, let alone be caused by it.
Nearly 100 Conclusions on the Health Effects of Marijuana and Cannabis-Derived Products Presented in New Report; One of the Most Comprehensive Studies of Recent Research on Health Effects of Recreational and Therapeutic Use of Cannabis and Cannabis-Derived Products
A new report from the National Academies of Sciences, Engineering, and Medicine offers a rigorous review of scientific research published since 1999 about what is known about the health impacts of cannabis and cannabis-derived products – such as marijuana and active chemical compounds known as cannabinoids – ranging from their therapeutic effects to their risks for causing certain cancers, diseases, mental health disorders, and injuries. Continue reading
I received this from a Marijuana Advocate organization:
A new President is about to take office, and we need to make sure we continue to move forward, not backward, on medical cannabis reform, in this administration. The time to start is NOW.
On Tuesday, January 10, 2017 (an earlier version of this email incorrectly said the 11th) the Senate Judiciary Committee will begin holding confirmation hearings on whether Senator Jeff Sessions (R-AL) will become the next U.S. Attorney General. Senator Sessions has been outspoken about his feelings regarding medical cannabis:
“I thank you for you and some of your officials in DEA for speaking out and telling the truth about the dangers of marijuana. This is not a non-dangerous drug.” Continue reading
Seniors Increasingly Getting High, Study Shows | Kaiser Health News | By Carmen Heredia Rodriguez December 6, 2016
Baby boomers are getting high in increasing numbers, reflecting growing acceptance of the drug as treatment for various medical conditions, according to a study published Monday in the journal Addiction.
The findings reveal overall use among the 50-and-older study group increased “significantly” from 2006 to 2013. Marijuana users peaked between ages 50 to 64, then declined among the 65-and-over crowd.
Men used marijuana more frequently than women, the study showed, but marital status and educational levels were not major factors in determining users
The study was based on 47,140 responses collected from the National Survey on Drug Use and Health.
Researchers also uncovered an increasing diversity in marijuana users. Past-year use doubled among married couples and those earning less than $20,000 per year.
More people living with medical conditions also sought out marijuana. The study showed the number of individuals living with two or more chronic conditions who used the drug over the past year more than doubled. Among those living with depression, the rate also doubled to 11.4 percent.
But unlike the marijuana of their youth, seniors living in states that legalized marijuana for medicinal use now can access a drug that has been tested for quality and purity, said Paul Armentano deputy director of NORML, a non-profit group advocating for marijuana legalization. Additionally, the plant is prescribed to manage diseases that usually strike in older age, pointing to an increasing desire to take a medication that has less side effects than traditional prescription drugs
The study found over half of the users picked up the habit before turning 18, and over 90 percent of them before age 36.
We are coming to a point where state lawmakers are responding to the rapidly emerging consensus-both public consensus and a scientific consensus — that marijuana is not an agent that possesses risks that qualifies it as a legally prohibited substance,” he said.
Pets on Pot: The Newest Customer Base for Medical Marijuana – The New York Times – By LAURA M. HOLSONOCT. 8, 2016
When Lisa Mastramico needed relief for her ailing tabby, Little Kitty, she turned to an unlikely source: marijuana.
“My concern was that it’s not my place to get my cat high,” said Ms. Mastramico
But with Little Kitty becoming increasingly isolated, it was time to give it a try. She got a medical marijuana card and purchased two edible oils made for pets and derived from cannabis that she squirts into her pet’s mouth. Continue reading
In 2014, after Colorado legalized the recreational use of cannabis, we began hearing that teen use was declining – contrary to prohibitionist propaganda.
Real-world data were beginning to prove that the black market, created through government prohibition, is a prime driver of negativites associated with drugs.
Another study performed by Washington University School of Medicine, published in May of this year, found that teen use of cannabis has significantly decreased as states legalize cannabis. Continue reading