Gabapentin, a drug for nerve pain, becomes a new target of abuse – By CARMEN HEREDIA RODRIGUEZ — KAISER HEALTH NEWS – JULY 6, 2017
Gabapentin is approved by the Food and Drug Administration to treat epilepsy and pain related to nerve damage, called neuropathy.
Also known by its brand name, Neurontin, the drug acts as a sedative.
It is widely considered non-addictive and touted by the federal Centers for Disease Control and Prevention as an alternative intervention to opiates for chronic pain. Continue reading
Pregabalin for acute and chronic pain in adults – free full-text PMC4167351 – 2009 Jul 8.
Background: Antiepileptic drugs have been used in pain management since the 1960s. Pregabalin is a recently developed antiepileptic drug also used in management of chronic neuropathic pain conditions.
Objectives: To assess analgesic efficacy and associated adverse events of pregabalin in acute and chronic pain.
There was no clear evidence of beneficial effects of pregabalin in established acute postoperative pain. Continue reading
Doctors may be over-prescribing seizure drugs to treat pain – chicagotribune.com – Dennis Thompson – Aug 2017
Physicians might be relying too heavily on “off-label” use of epilepsy drugs as an alternative to prescribing narcotic painkillers, two experts in internal medicine contend.
Doctors are prescribing the anti-seizure drugs gabapentin (Neurontin) and pregabalin (Lyrica) to treat pain more frequently, partly in response to the opioid epidemic in the United States, said Dr. Allan Brett. He’s a professor of clinical internal medicine with the University of South Carolina School of Medicine in Columbia.
However, the drugs might not be doing any good for many people suffering from chronic pain, Brett said. Continue reading
Duration of Antibiotic Therapy: General Principles – Pharmacy Times – Maricelle O. Monteagudo-Chu, PharmD, BCPS-AQID, and Nageh Shaeishaa, RPH, MSC – July 2017
Deciding on the duration of antimicrobial therapy for an infection is neither straightforward nor simple. A short or long course of antibiotics can be given to a patient, depending on the drug used, the severity of an infection, and response to treatment (Table 1).
Original image is blurry too
Study Answers Why Ketamine Helps Depression, Offers Target for Safer Therapy – June 21, 2017
UT Southwestern Medical Center scientists have identified a key protein that helps trigger ketamine’s rapid antidepressant effects in the brain, a crucial step to developing alternative treatments to the controversial drug being dispensed in a growing number of clinics across the country.
Ketamine is drawing intense interest in the psychiatric field after multiple studies have demonstrated it can quickly stabilize severely depressed patients.
But ketamine – sometimes illicitly used for its psychedelic properties – could also impede memory and other brain functions, spurring scientists to identify new drugs that would safely replicate its antidepressant response without the unwanted side effects. Continue reading
Anti-inflammatory drugs ‘no better than placebo’ for back pain: study – ABC News (Australian Broadcasting Corporation) – By medical reporter Sophie Scott and National Reporting Team’s Rebecca Armitage – Feb 2017
“Compared with placebo, non-steroidal anti-inflammatory drugs (NSAIDs) do not provide a clinically important effect on spinal pain,” Associate Professor Manuela Ferreira said.
And below you can read about a study showing that chiropractic is as effective as NSAIDs (anti-inflammatories). So, NSAIDs and chiropractic are both only as effective as a placebo.
Researchers found six patients had to be treated with anti-inflammatory drugs for one patient to achieve a clinically important benefit in the short-term. Continue reading
Tricyclic antidepressants are recommended by the CDC for chronic pain but my research shows they have a vast number of and types of side effects affecting most bodily systems.
I’m outraged that these dangerous and “dirty” (having effects on many other biological systems) drugs are being pushed on us by our government.
Straight from the CDC guideline:
Several nonpharmacologic and nonopioid pharmacologic treatments have been shown to be effective in managing chronic pain in studies ranging in duration from 2 weeks to 6 months. For example… Continue reading
The antibiotic course has had its day | The BMJ – July 2017
With little evidence that failing to complete a prescribed antibiotic course contributes to antibiotic resistance, it’s time for policy makers, educators, and doctors to drop this message, argue Martin Llewelyn and colleagues.
Antibiotics are vital to modern medicine and antibiotic resistance is a global, urgent threat to human health. The relation between antibiotic exposure and antibiotic resistance is unambiguous both at the population level and in individual patients.
However, the idea that stopping antibiotic treatment early encourages antibiotic resistance is not supported by evidence, while taking antibiotics for longer than necessary increases the risk of resistance. Continue reading
How does the body process pain? Study sheds new light – Medical News Today by Ana Sandoiu – June 2017
Currently available pain medications have limited efficacy and numerous side effects. New research, however, provides deeper insights into how our bodies process pain, paving the way for an innovative, more effective way of targeting chronic pain.
According to recent estimates from the National Institutes of Health (NIH), as many as 25 million people in the United States live with daily pain, and 23 million of the country’s adults have more severe pain.
Previous efforts to develop more effective analgesics have been stalled by our limited understanding of the mechanisms that allow nerves to sense and transmit pain signals,” Dr. Bunnett says. Continue reading
The Myth of Drug Expiration Dates – ProPublica
The box of prescription drugs had been forgotten in a back closet of a retail pharmacy for so long that some of the pills predated the 1969 moon landing. Most were 30 to 40 years past their expiration dates
the cache was an opportunity to answer an enduring question about the actual shelf life of drugs: Could these drugs from the bell-bottom era still be potent?
The age of the drugs might have been bizarre, but the question the researchers wanted to answer wasn’t. Continue reading