Evidence Lacking for Current Pharmacologic Treatment of Neuropathic Pain – Pain Medicine News – May 19, 2017
Successful management of neuropathic pain remains elusive despite the variety of pharmacologic classes prescribed to treat it, new research suggests.
Furthermore, the actual evidence supporting drugs used on an everyday basis is remarkably deficient, according to Richard W. Rosenquist, MD, the study’s author and chairman of the Department of Pain Management at the Cleveland Clinic, in Ohio
The Cleveland Clinic has become notorious for denying opioid pain medication to patients who desperately need them. Continue reading
Counterfeit Drugs: The Silent Epidemic | Do No Harm – May 27, 2012 – by Do No Harm Inc.
As much as 15% of medicines in the world are counterfeit thus causing 100,000 deaths worldwide according to the WHO. The increase of counterfeit drugs across the world in the last decade is both a consequence and a symptom of one phenomenon: the globalization of drugs production and distribution. The supply chain of medicines has become increasingly fragmented and scattered across the globe with raw material extraction taking place in one country and ingredients synthesis and formulation in another country. This globalized supply chain has two implications:
It makes the counterfeit drugs problem not an exclusivity of developing countries: developed countries are as much exposed to this risk as least developed countries.
If the problem is global, the solution has to be global too. As long as pharmaceutical companies source their active pharmaceuticals ingredients (APIs) in other countries any regulation which is purely domestic is bound to be ineffective. Continue reading
FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects
This information is an update to the FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together issued on May 12, 2016
Some signs and symptoms of serious side effects include:
- unusual joint or tendon pain,
- muscle weakness,
- a “pins and needles” tingling or pricking sensation,
- numbness in the arms or legs,
- confusion, and
Opioids vs. NSAIDs for Chronic Pain — Pain News Network– May 11, 2017 – By Roger Chriss, Columnist
…Minneapolis Star Tribune reporting on a new study that found “patients with chronic pain fared no better with the potentially addictive painkillers than they did with non-opioid meds.”
“If pain doctors still think these medicines are effective, then they have a lot of explaining to do and their competence and professionalism deserve to be challenged,” said Chris Johnson, MD, who is a board member of PROP as well as the Steve Rummler Hope Foundation.
But the study did not show that opioids were ineffective, only that non-opioids were more effective in this particular study. Continue reading
Despite the CDC’s recommendation that pain treatment utilize non-opioid medications, like Lyrica, there is no evidence for its effectiveness in one of the most common pains: sciatica.
Pregabalin for sciatica, increasing prescription but is it effective? by Stephanie Mathieson – Body in Mind
Few clinical guidelines for the treatment of sciatica exist and evidence regarding effective medical treatments is limited. One medicine that is prescribed for the management of sciatica is pregabalin (also known as Lyrica®). Continue reading
Lyrica and Neurontin Linked to Opioid Overdoses — Pain News Network – May 2017
“It is important that doctors and people dependent on opioids are aware that the number of overdose deaths involving the combination of opioids with gabapentin or pregabalin has increased substantially and that there is evidence now that their concomitant use – either through co-prescription or diversion of prescriptions – increases the risk of acute overdose deaths,” said Matthew Hickman, a Professor of Public Health and Epidemiology
The idea that Lyrica and Neurontin are being abused may be surprising to many patients and doctors, but the drugs are increasingly being used by addicts. Continue reading
New activity for anti-inflammatory drugs | National Institutes of Health (NIH) | Mar 2017
Scientists sometimes find novel uses for old drugs. For example, the common pain reliever aspirin is now used by millions of people to help prevent heart attack, stroke, or certain cancers.
Aspirin is a type of non-steroidal anti-inflammatory drug (NSAID). Because aspirin has found multiple uses, other NSAIDs might also have health benefits that haven’t yet been discovered.
Aspirin and other NSAIDs are known to have anti-inflammatory effects by inhibiting COX (cyclooxygenase) enzymes. These enzymes are pivotal in the inflammatory process. Continue reading
Pain Relievers Tied to Immediate Heart Risks – The New York Times
The pain relievers known as nonsteroidal anti-inflammatory drugs, or Nsaids, are known to carry heart risks. A new analysis found that those risks can arise within a week of starting the drugs.
Researchers did a systematic review of studies involving more than 446,000 people ages 40 to 79, of whom more than 61,000 had heart attacks
In those who used Nsaids one to seven days, the risk of heart attack increased
- 24 percent for celecoxib (Celebrex),
- 48 percent for ibuprofen (Advil, Motrin),
- 50 percent for diclofenac (Voltaren), and
- 53 percent for naproxen (Aleve).
- 58 percent for rofecoxib (Vioxx), which was taken off the market in 2004 because of its cardiovascular risks.
The study, in BMJ, found that the risk increases with higher doses and duration of treatment, but there was no significant increase in risk after one month of taking the drugs.
The lead author, Michèle Bally, an epidemiologist at the University of Montreal Hospital, said that the absolute increase in risk is quite small, since the risk of heart attack for most people is small to begin with.
Cholesterol Paradox: A Correlate Does Not a Surrogate Make – Robert DuBroff – Evid Based Med. 2017
The global campaign to lower cholesterol by diet and drugs has failed to thwart the developing pandemic of coronary heart disease around the world.
Some experts believe this failure is due to the explosive rise in obesity and diabetes, but it is equally plausible that the cholesterol hypothesis, which posits that lowering cholesterol prevents cardiovascular disease, is incorrect.
The public is certainly not aware that lowering cholesterol to prevent heart disease is just a theory because, as is the case with most things medical, it is presented as a fact.
This is exactly what has happened with opioids, making the public believe that these effective medications are useless for chronic pain and always horrendously addictive for all people under all circumstances. Continue reading
Depression Management during the Presence of Pain: An Overview – January 20, 2015 – free full text article
Depression and anxiety are frequently associated with increased risk of medical problems. The severity of these problems varies from persistent pain to severe cardiovascular illness.
The pathophysiology of chronic pain and depression overlap in the noradrenergic and serotonergic pathways.
Antidepressants, especially dual acting which affect both pathways, are a frequent and effective choice of treatment for chronic pain.
The effectiveness of antidepressants for pain has not been proven and many pain patients get zero relief from them, including me.n Continue reading