Anxiety Disorders Linked to Disturbances in the Cells’ Powerhouses [Mitochondria] 19-Sep-2019 1 Newswise
The powerhouse of the cell, the mitochondria, provides energy for cellular functions. But those activities can become disturbed when chronic stress leads to anxiety symptoms in mice and humans. Iiris Hovatta of the University of Helsinki and colleagues report these findings in a new study published 26th September in PLOS Genetics.
Chronic stress due to stressful life events, such as divorce, unemployment, loss of a loved one and war, are a major risk factor for developing panic attacks and anxiety disorders.
This is not only proven, but also intuitively true, as we know from our own lives, once beset by chronic pain. Continue reading
People Who Commit Suicide Have Abnormal Chromosomes, Mitochondria | American Council on Science and Health – By Alex Berezow — June 14, 2017
Views toward suicide have changed in recent decades. Once largely perceived as a selfish act and a “permanent solution to a temporary problem,” society has become more compassionate toward those who suffer in silence. This is an enormously positive development, and it is likely an outgrowth of our greater understanding of mental illness.
The causes of suicide are complex, but they seem to involve some combination of nature (genetics) and nurture (culture and environment).
According to the CDC, the suicide rate in the U.S. in 2015 grew to 15.7 per 100,000, sparking fears of a “suicide epidemic.” Continue reading
Study Suggests “Bad Energy” is Core Problem in Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS) – Health Rising – by Cort Johnson | May 31, 2017
Lactate has become a big deal in both chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM). A by-product of anaerobic energy metabolism, lactate ordinarily gets pumped out of our cells in large amounts during exertion.
The lactate findings suggest that the energy needs of ME/CFS/FM patients are largely being addressed by glycolysis or anaerobic energy production.
Anaerobic energy production plays an important role in energy production, but when aerobic energy production is not available and it becomes the major source of energy it produces metabolites that produce the burning muscles, fatigue and other symptoms we associate with over-exercise. Continue reading
Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME
Though this article refers to Chronic Fatigue Syndrome, these symptoms often overlap with other chronic conditions, like Fibromyalgia. Also, people with EDS are often suspected of having mitochondrial issues.
It has been well documented that there is an abnormal increase in cytokines (chemicals released by the immune system) in CFS/ME patients following mild exercise. This causes another type of fatigue on top of the mitochondrial dysfunction fatigue discussed below. Cytokines in general, without the exercise trigger, can cause fatigue. There are probably additional causes of fatigue (such as orthostatic intolerance) as well.
Role of mitochondria in cellular function
Lactate – Is it Everywhere in Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)? – Health Rising
Lactate (L-lactate) is an organic compound produced during anaerobic energy metabolism.
It’s constantly being formed – even when we are at rest – but is formed in higher quantities when ATP levels are low and anaerobic energy metabolism is high. Several forms of lactate are also produced by anaerobic bacteria in the gut.
Lactate is not bad – it actually reduces muscle fatigue – but the presence of high levels of lactate (lactic acid) signal that the anaerobic energy production process – which produces toxic metabolites that cause pain and fatigue – is in full bore. Continue reading
Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism | 2008 | Free Full Text
HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all medications have potential for adverse effects (AEs).
Here we review the statin AE literature, first focusing on muscle AEs as the most reported problem both in the literature and by patients.
Evidence regarding the statin muscle AE mechanism, dose effect, drug interactions, and genetic predisposition is examined. Continue reading
Is Lactic Acidosis Behind Many Chronic Fatigue Syndrome / Fibromyalgia Symptoms? By Ken Lassesen | October 12, 2015
As a person who’s been gifted with being in remission from chronic fatigue syndrome (for the third time), I adhere to a model of what I believe causes typical ME/CFS in hope of staying in remission.
The model is stable and consistent with the latest (and older) research studies. It follows William Osler’s principle basing diagnosis and treatment on a strict observation of symptoms (not forgone conclusions and KISS (Keep It Simple Stupid).
“Listen to your patient, he is telling you the diagnosis”
– William Osler
Abundant Energy Summit: Dr. Myhill speaks about the role of mitochondrial function in ME/CFS
This is from an interview with Dr. Myhil about the central role of mitochondria in fatigue. She believes that CFS/ME is a cluster of symptoms that can have many causes. She’s the author of the book, It’s Mitochondria Not Hypochondria
Q: You have a car analogy in your book. Please explain that.
Let’s start from the beginning. The first and most important thing to grasp about Chronic Fatigue Syndrome is that it is not a diagnosis, it is a clinical picture that may have many causes. Continue reading
Mitochondrial Depletion Could Underlie the Energy Problems in Chronic Fatigue Syndrome – Health Rising
Debilitating fatigue is a symptom of many other illnesses, like EDS, and reduced mitochondrial capacity could be the culprit.
a model exploring mitochondrial dynamics – may help explain what’s causing the post-exertional problems
this study extended a well-known metabolic model explaining what happens to the mitochondria in the skeletal muscles during exercise. The authors enhanced it by adding some processes to it (lactate accumulations / purine degradation) known to occur in the mitochondria.
Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | PLoS One. 2015 Mar | free full text PubMed
Acetyl-L-carnitine (ALC), a constructive molecule in fatty acid metabolism, is an agent potentially effective for treating peripheral neuropathic pain (PNP). Its effect, however, remains uncertain. We aimed to access the efficacy and safety of ALC for the treatment of patients with PNP.
The current evidence suggests that ALC has a moderate effect in reducing pain measured on VAS in PNP patients with acceptable safety. Larger trials with longer follow-up, however, are warranted to establish the effects. Continue reading