Impact of Melatonin on Skeletal Muscle and Exercise – free full-text /PMC7072499/ – Cells. Feb 2020
Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life.
Melatonin, the indole produced at nighttime in pineal and extra-pineal sites in mammalians, has recognized anti-aging, anti-inflammatory, and anti-oxidant properties.
Mitochondria are the favorite target of melatonin, which maintains them efficiently, scavenging free radicals and reducing oxidative damage. Here, we discuss the most recent evidence of dietary melatonin efficacy in age-related skeletal muscle disorders in cellular, preclinical, and clinical studies.