Tag Archives: neuropathy

Opioids Effective for Peripheral and Neuropathic Pain

Oral opioid therapy for chronic peripheral and central neuropathic pain. – PubMed – NCBI – Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, School of Medicine, San Francisco, USA – free full-text in N Engl J Med. – Mar 2003

This careful and rigorous study from 15 years ago showed clearly that an opioid, at least levorphanol, can be very effective for “central sensitization” types of pain.

I suspect the current doubts about opioid effectiveness for neuropathic pain are because they are afraid to use strong enough opioids in sufficient doses, because this article shows levorphanol IS effective.


Although opioids are commonly used to treat chronic neuropathic pain, there are limited data to guide their use. Few controlled trials have been performed, and many types of neuropathic pain remain unstudied.  Continue reading

Nociceptive versus Neuropathic Chronic Low Back Pain

Distinguishing between nociceptive and neuropathic components in chronic low back pain using behavioural evaluation and sensory examination – free full-text /PMC5329124/ article – Feb 2017

Diagnosis of chronic low back pain (CLBP) is traditionally predicated on identifying underlying pathological or anatomical causes, with treatment outcomes modest at best.

Alternately, it is suggested that identification of underlying pain mechanisms with treatments targeted towards specific pain phenotypes may yield more success.

Differentiation between nociceptive and neuropathic components of CLBP is problematic; evidence suggests that clinicians fail to identify a significant neuropathic component in many CLBP patients.   Continue reading

Neuropathic, Non-Neuropathic, and Mixed Pain

Distinguishing Neuropathic, Non-Neuropathic, and Mixed Pain – May 2017 – By Charles E. Argoff, MD

Given the complexity of chronic pain management, clinicians are challenged to move toward more rigorous assessment and individualized treatment to improve quality of life for all patients.

It has become increasingly clear that chronic pain does not refer to one disorder or underlying mechanism and cannot be assessed or treated with a one-size-fits-all approach

Advances in our understanding have led to new, more effective patient assessment and treatment strategies.  Continue reading

Treatment of Neuropathic Pain

Treatment of Neuropathic Pain – Pharmacy Times – Jeffrey Fudin, PharmD, DAAPM, FASHP, FCCP; Jeffrey Bettinger, PharmD Candidate; and Erica Wegrzyn, BA, BS, PharmD  – Apr 2017

INeuropathic pain is somatosensory system disease or damage, which can be caused by a wide variety of nerve-damaging diseases or medications affecting the peripheral or central nervous system

Definitions and Pathophysiology of Neuropathic Pain

Neuropathic pain has been described as “pain initiated or caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system.”   Continue reading

Different Drugs for Different Types of Neuropathic Pain

Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: Data from the randomized, double-blind, COMBO-DN study

Sensory profiles are heterogeneous in neuropathic pain disorders, and subgroups of patients respond differently to treatment.

To further explore this, patients in the COMBO-DN study were prospectively assessed by the Neuropathic Pain Symptom Inventory (NPSI) at baseline, after initial 8-week therapy with either duloxetine or pregabalin, and after subsequent 8-week combination/high-dose therapy. Exploratory post hoc cluster analyses were performed to identify and characterize potential subgroups through their scores in the NPSI items

In patients not responding to initial 60 mg/d duloxetine,

  • adding 300 mg/d pregabalin for combination treatment was particularly effective regarding the dimensions pressing pain and evoked pain,
  • whereas maximizing the duloxetine dose to 120 mg/d appeared more beneficial regarding paresthesia/dysesthesia.   Continue reading

Ehlers-Danlos Syndrome Linked to Small-Fiber Neuropathy

Ehlers-Danlos Syndrome Linked to Small-Fiber Neuropathy

Recently, we’ve seen several individuals at our center who have Ehlers-Danlos syndrome (EDS), a known connective tissue disorder associated with, among other things, hyperelasticity. Although there are several types of EDS, that’s not the focus of today’s blog post.

People have been referred to us who have severe and chronic pain of uncertain etiology.

Although it’s been well documented that people with EDS do experience chronic pain of varying quality, other conditions, fatigue, and pain- and fatigue-related disability, overall this syndrome has been poorly understood.   Continue reading

CB2 receptors: Pain Tx Without Tolerance or Withdrawal

Cannabinoid Receptor 2: Pain Treatment Without Tolerance or Withdrawal – reposted with edits from April 2015

This article about a promising new medicine derived from cannabis  was published by the National Institute on Drug Abuse (NIDA), on their site “drugabuse.gov.  (Other branches of the same government, FDA and DEA, still classify cannabis as a Schedule I drug,)

Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal.

The treatment of cancer pain is often among the approved uses of medical cannabis in states where it is legal.   Continue reading

Cannabis Eases Neuropathic Pain

Vaporized Cannabis Eases Neuropathic Pain in Patients with Spinal Cord Injury

researchers investigated the use of vaporized cannabis for neuropathic pain (NeP) in patients with spinal cord injury (SCI) or disease.

NeP in SCI patients may result from altered sensory processing due to the injury.

Spinal cord injury patients treated with vaporized cannabis had a significant analgesic response over placebo.   Continue reading

Neuropathic pain: a maladaptive response of the nervous system

Review from practicalpainmanagement.com:

PainScan Abstract | Neuropathic pain: a maladaptive response of the nervous system

This article provides a useful overview of neuropathic pain.  The authors begin by distinguishing it from other types of pain (nociceptive, inflammatory, and dysfunctional).  They then go on to describe neurobiological mechanisms involved in neuropathic pain. Continue reading

Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain

Acetyl-L-Carnitine in the Treatment of Peripheral Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | PLoS One. 2015 Mar | free full text PubMed


Acetyl-L-carnitine (ALC), a constructive molecule in fatty acid metabolism, is an agent potentially effective for treating peripheral neuropathic pain (PNP). Its effect, however, remains uncertain. We aimed to access the efficacy and safety of ALC for the treatment of patients with PNP.


The current evidence suggests that ALC has a moderate effect in reducing pain measured on VAS in PNP patients with acceptable safety. Larger trials with longer follow-up, however, are warranted to establish the effects.  Continue reading