Tag Archives: opioids

Response to FDA’s Request to Pull Opana Off Market

AIPM’s Response to FDA’s Request to Pull Opana ER Off Market – Academy of Integrative Pain Management Blog

On Thursday, June 8, the U.S. Food and Drug Administration “requested that Endo Pharmaceuticals remove its opioid pain medication, reformulated Opana ER (oxymorphone hydrochloride), from the market,” the FDA said in a statement.

Apparently Opana ER, an extended release form of the opioid drug oxymorphone, was being crushed up and injected by people seeking to abuse it.

“After careful consideration, the agency is seeking removal based on its concern that the benefits of the drug may no longer outweigh its risks. This is the first time the agency has taken steps to remove a currently marketed opioid pain medication from sale due to the public health consequences of abuse.”   Continue reading

THC Potentiates Analgesic Effects of Opioids

Persistent Potentiation of the Analgesic Effects of Opioids by Delta-9Tetrahydrocannabinol (THC) in Nonhuman Primates – Apr 2017

Improving the analgesic effectiveness of opioids while also reducing the adverse effects is a major goal of pain research.

One approach to this problem has been to combine drugs such as cannabinoids with opioids to determine if this might reduce the dose of opioid required to produce analgesia.

In this experiment, male nonhuman primates (rhesus macaques) were administered a range of doses of THC in combination with cumulative doses of heroin to determine if the combinations produced greater analgesia than that observed with heroin alone.

Briefly, the animals were secured in standard primate ch  airs, tails were shaved, and dipped in a mixed order in three different water temperatures (40 °, 50 °, and 55 °C) until the animal rapidly withdrew his tail, or 20 seconds elapsed. Continue reading

Effective Opioids Declared Ineffective

Effective Opioids Declared Ineffective – by Zyp Czyk

In all the reporting about pain research, opioids are always declared ineffective for long-term chronic pain relief.

The full truth is that there have been NO long term studies and there is NO evidence proving they are INeffective either, but that isn’t mentioned.

This situation allows doctors and researchers to state only one side of the full truth, that there is no evidence opioids are effective and still feel like they are telling the “truth”.

This half-truth has created a nightmare scenario for pain patients:  Continue reading

An Opioid Survey and a Maternal Chronic Pain Study

Opioid Survey re Overdose Epidemic

This is an inclusive survey for all opioid users (legitimate or illegal), their family members, and physicians. It seems designed to capture a comprehensive snapshot of the situation.

We’re interested in hearing about how the opioid epidemic and the public health response to it are affecting patients and doctors, family members and addicts.

This survey will be used by the Bend Bulletin, a daily newspaper in Bend, Oregon, to gather information on how the opioid epidemic has impacted different types of people, and to track how efforts to address the crisis are impacting them.

A unique characteristic of the survey is that it does not assume you are either a patient of a person with addiction, but lets you state your relationship to these drugs:   Continue reading

Hyperalgesia: No Reason to Stop or Reduce Opioids

Hyperalgesia: No Reason to Stop or Reduce Opioids – May 30, 2017 – by Forest Tennant M.D., Dr. P.H.

One of the excuses that some health practitioners are using to stop opioids is to claim a patient has hyperalgesia (HA).

This is a most dishonest, devious, and dangerous ploy.

First, the definition of hyperalgesia is simply that a stimulus such as hitting your thumb with a hammer is more painful than usual.

Second, there is no way to measure or quantify the presence of HA in a chronic pain patient who takes opioids.  Continue reading

Mu-Opioid Receptors Drive Tolerance in Mice

Mu-Opioid Receptors on Nociceptors, Not Microglia, Drive Morphine Tolerance and Hyperalgesia in Mice | Pain Research Forum | by Matthew Soleiman – Feb 2017

By genetically removing mu-opioid receptors (MORs) from peripheral nociceptive neurons, the researchers found that they could reduce both tolerance and OIH while maintaining analgesia in mice receiving daily doses of morphine.

“The main take-away from the paper is that you can dissociate the side effects of opioids from the main effect of analgesia,”

What’s more, administration of morphine along with a peripherally restricted MOR antagonist also lessened tolerance and OIH without diminishing analgesia in models of perioperative and chronic pain.   Continue reading

Opioids vs. NSAIDs for Chronic Pain

Opioids vs. NSAIDs for Chronic Pain — Pain News Network– May 11, 2017 – By Roger Chriss, Columnist

Minneapolis Star Tribune reporting on a new study that found “patients with chronic pain fared no better with the potentially addictive painkillers than they did with non-opioid meds.”

“If pain doctors still think these medicines are effective, then they have a lot of explaining to do and their competence and professionalism deserve to be challenged,” said Chris Johnson, MD, who is a board member of PROP as well as the Steve Rummler Hope Foundation.

But the study did not show that opioids were ineffective, only that non-opioids were more effective in this particular study.  Continue reading

Abuse-Deterrent Opioids A Double-Edged Sword

Are Abuse-Deterrent Opioid Products A Double-Edged Sword? – Practical Pain Management – May 16, 2017 – By Jasmine Shah, PharmD and Ryan W Rodriguez, PharmD, BCPS

Solving the opioid epidemic is complex because of the multifactorial underlying causes. Complicating this issue is the need to maintain access to opioids for patients with chronic pain conditions for which prescription opioid analgesics are the only effective treatment.

Any attempts to mitigate opioid abuse must not have the unintended consequence of eliminating a viable treatment option for patients using opioid medications appropriately and experiencing meaningful clinical improvement.  Continue reading

Patient-Focused Guideline for Prescription Opioids

The CDC’s Fictitious Opioid Epidemic, Part 2 | Journal of Medicine | Medical Journals | National College of Physicians – By Richard A. Lawhern, Ph.D

A CDC Guideline for prescribing opioids in chronic pain was published in March 2016. It has become clear that this [CDC] Guideline is generating horrendously negative results for both chronic pain patients and their doctors.

Many doctors are choosing to leave pain management rather than face possible prosecution by State or Drug Enforcement Agency authorities for over-prescription of pain relieving opioids.

Tens (if not hundreds) of thousands of patients are being summarily discharged without referral and sometimes without management of opioid withdrawal. There are increasing reports of patient suicides.   Continue reading

The Rest of the Opioid Story

The Rest of the Opioid Story — Pain News Network – April 04, 2017 – By Roger Chriss, Columnist

Media reports about the opioid crisis in the U.S. are often grim and sensational.

The Economist declares that “states are losing the battle against deadly drugs like heroin and fentanyl.” Vox describes the opioid epidemic as “America’s worst drug crisis ever.” And CBS News warns that “opioid dependence can start within just a few days.”

But all this ignores a key point: Opioids are the best pain reliever we have, and they relieve a lot of pain.   Continue reading