Tag Archives: research

Increased use of heroin as an initiating opioid of abuse

Increased use of heroin as an initiating opioid of abuse. – PubMed – NCBI – Addict Behav. 2017 Nov;

Note to CDC: data now clearly show that prescribed opioids are *not* the initiating drugs for addiction and fatal overdoses, so stop harassing pain patients!

Given the relatively recent growth in access to heroin and a more permissive atmosphere surrounding its use, we hypothesized that an increasing number of persons with limited experience and tolerance to opioids would experiment with heroin as their first opioid rather than more common prescription opioid analgesics. 

Spoiler alert: their hypothesis was proven true. Continue reading

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CDC Removes Disproven CFS Therapies From Website

CDC Removes Reference to Disputed Chronic Fatigue Therapies From Website – 07.26.2017 / By David Tuller

This is another case of the CDC promoting faulty therapies for chronic illness.

I used to think that the CDC, with its access to all global research, was the final authority on general health care. But now I’m disillusioned about this powerful government agency after finding nonsense therapies being promoted for other problems, like chronic fatigue, not just chronic pain.

For years, the U.S. Centers for Disease Control and Prevention recommended two controversial treatments for ME/CFS, the illness often known as chronic fatigue syndrome:

  1. a program of steadily increasing activity, and
  2. a specific form of cognitive behavior therapy. Continue reading

Stanford Study: ME/CFS is Inflammatory Disorder

Major Stanford Study Indicates Chronic Fatigue Syndrome (ME/CFS) is Inflammatory Disorder – Simmaron Research By Cort Johnson – August 11, 2017

The study examined the levels of a very large number of cytokines (n=51) in the blood of a very large number of patients and healthy controls (ME/CFS=186; healthy controls= 388). Age, sex, race and something called “nonspecific binding” were accounted for.

One of the biggest ME/CFS immune studies ever undertaken, done at a top University, this was a study that we dearly didn’t want to fail.

This is the kind of study likely to be labeled “definitive”.  Continue reading

Opioids Blamed for Consequences of Chronic Pain

This is an essay I wrote out of sheer frustration

I’ve noticed a consistent error in the latest research on opioid therapy: All negative outcomes of opioid/pain research are attributed to the opioid medications instead of the underlying pain.

Researchers willfully ignore that opioids were originally prescribed for unbearable pain and proceeded as though the motivation for these medications were insignificant or irrelevant to their studies.

The many detrimental outcomes these studies find are exactly what you’d expect from a person suffering long-term chronic pain. But researchers place the blame for any negative outcomes on the opioid medications taken to relieve pain, not on the pre-existing pain itself.  Continue reading

ADHD and reward deficiency syndrome

This PubMed article piqued my interest because of the following paragraphs which seem an uncanny description of the hyper-sensitivity that so many of us suffer from.

It may be that people with ADHD are afflicted with a defective filtering system such that their brainstem reticular formation does not block out irrelevant stimuli. These people appear to be aware of every sound, every object, every touch, and they all merge in disorganized behaviors that are difficult to tolerate

At a deeper level, ADHD is a problem of communication among brain cells, or neurons, possibly involving the neurotransmitters that carry inter-neural messages. If the messengers that inhibit incoming stimuli are deficient, too many signals get through and create confusion.

Attention-deficit-hyperactivity disorder and reward deficiency syndrome – free full-text PMC2626918 – 2008 Oct;   Continue reading

Pain Tolerance and C-reactive protein

C-reactive protein and cold-pressor tolerance in the general population : PAIN – July 2017

Pain and inflammation are related: systemic inflammation may lead to a variety of pain states, and, in turn, persistent pain causes an upward adjustment of proinflammatory mediators that sometimes elicit a prolonged low-grade immune response, leading to long-lasting, subclinical inflammation.

The cytokines that are produced during inflammatory responses are the main stimulators of the production of acute-phase proteins, specifically C-reactive protein (CRP).

C-reactive protein is a nonspecific systemic marker of infection, inflammation, tissue damage, malignancy, and autoimmune disease.  

Continue reading

Opioids for chronic pain: meta-analysis from 2006

Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects – 2006 May – free full-text PMC1459894

This meta-analysis was carried out with these objectives:

  1. to compare the efficacy of opioids for CNCP with other drugs and placebo;
  2. to identify types of CNCP that respond better to opioids; and
  3. to determine the most common side effects of opioids.   Continue reading

Population Statistics do NOT Apply to Individuals

Statistics and the Rise of Medical FortunetellersMichel Accad, MD – Tex Heart Inst J. 2009; free full-text PMC2801944

This article makes the increasingly forgotten, yet increasingly important, point that population statistics do NOT apply to individuals.

There was a time when the foretelling of future events was an undertaking of prophets, palm-readers, and weathermen. In recent years, however, the medical profession seems to have embraced this activity with a great deal of enthusiasm.

But hyperbole is also what comes to mind when one examines the claims that authors of such reports make.   Continue reading

How Systematic Review and Meta-Analysis Work

How Systematic Review and Meta-Analysis Work | American Council on Science and Health -By Chuck Dinerstein — June 23, 2017

…I thought perhaps this was a time to explain systematic reviews (SR) and their closely related kin, the meta-analysis (MA).

Keeping up with the latest thinking and knowledge, even for specialists, is challenging.

Textbooks, given the time necessary to write, edit and print are repositories for the accepted ‘dogma.’

Journals and conferences bring new information forward more quickly. But even then it is difficult for individuals to synthesize multiple articles and sources to ‘know’ what is both correct and useful.   Continue reading

Surrogate end points in clinical research: Hazardous

Surrogate end points in clinical research: hazardous to your health. – PubMed – NCBI – Obstet Gynecol. 2005 May

Surrogate end points in clinical research pose real danger.

A surrogate end point is an outcome measure, commonly a laboratory test, that substitutes for a clinical event of true importance.

Resistance to activated protein C, for example, has been used as a surrogate for venous thrombosis in women using oral contraceptives.

Other examples of inappropriate surrogate end points in contraception include the  Continue reading