Microglia may be the missing clue to solve the opioid epidemic – Sara Whitestone – Neuroscience – Université de Bordeaux – May 2019
…neuroscientists have discovered a new therapeutic target for managing pain: microglia.
Pain, as an acute sensation, serves as a warning to help your body prevent injury or avoid further harm.
the message from your stubbed toe is forced to go through a series of checkpoints—or gates—which will either open or shut to control the intensity of pain you perceive.
When pain becomes chronic, this signaling and the gate controls go haywire. Nerves become hyper-sensitive, firing off messages to the brain even in the absence of an injury. Continue reading
Protein Waves In Blood Linked To Aging Process: Shots – Health News : NPR – by Richard Harris – Dec 2019
Scientists know that if they transfuse blood from a young mouse to an old one, then they can stave off or even reverse some signs of aging. But they don’t know what in the blood is responsible for this remarkable effect.
Researchers now report that they’ve identified hundreds of proteins in human blood that wax and wane in surprising ways as we age.
Wyss-Coray and his colleagues report in Nature Medicine on Thursday that these proteins change in three distinct waves, the first of which happens “very surprisingly” during our 30s, peaking around age 34. Continue reading
The Effects of Voluntary, Involuntary, and Forced Exercises on Brain-Derived Neurotrophic Factor and Motor Function Recovery: A Rat Brain Ischemia Model – free full-text /PMC3035657/ – Feb 2011
I was happy to find that what I have personally experienced has been proven to be true: forced exercise is not as beneficial as voluntary. Sometimes science actually proves our intuitions correct – surprise!
Stroke rehabilitation with different exercise paradigms has been investigated, but which one is more effective in facilitating motor recovery and up-regulating brain neurotrophic factor (BDNF) after brain ischemia would be interesting to clinicians and patients.
Here are 4 PubMed scientific studies exploring how estrogen affects all different aspects of pain: its sensation, its interaction with opioid receptors, and its memory. Estrogen is clearly important, but the interactions with pain sensation are very complex.
Just like with hormone replacement therapy, the effects of estrogen on pain probably differ a great deal between individuals.
Pronociceptive and Antinociceptive Effects of Estradiol through Endogenous Opioid Neurotransmission in Women – NCBI – May 2006
Prominent interindividual and sex-dependent differences have been described in responses to sustained pain and other stressful stimuli. Variations in μ-opioid receptor-mediated endogenous opioid neurotransmission may underlie some of these processes. Continue reading
The trouble with mice as behavioral models for Alzheimer’s – STAT – By Adam Rosenberg – Apr 2019
It is becoming increasingly obvious that rodents cannot accurately model human diseases, let alone human behaviors.
I’ve always doubted the findings of pain studies that use rodents because these animals cannot possibly model what is claimed to be a bio-psycho-social syndrome.
There’s been a lot of talk about overinvestment in interventions aimed at amyloid in the weeks since Biogen discontinued a late-stage study of aducanumab, an experimental therapy for Alzheimer’s disease. Continue reading
The effects of opioids on cognition in older adults with cancer and chronic non-cancer pain: A systematic review. – PubMed – NCBI – J Pain Symptom Manage. Oct 2019
Opioids are prescribed to manage moderate to severe pain and can be used with older adults; however, they may lead to several adverse effects, including cognitive impairment.
To identify, appraise and synthesise evidence on
- i) the impact of opioids on cognition in older adults with cancer/chronic non-cancer pain, and
- ii) screening tools/neuropsychological assessments used to detect opioid-induced cognitive impairment.
Because fascia is made from collagen, the genetic defect from EDS will often cause us problems with this tissue. It’s thin, fragile, stretches too much, and gives way too easily.
PubMed Central® (PMC) is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health’s National Library of Medicine (NIH/NLM).
Research on the body’s fascia (connective tissue) is finding more and more of its functions and abilities, going far beyond just “holding stuff together”. I’ve posted here the abstracts of the following 4 articles and you can decide for yourself if they’re worth reading in full.
- Smooth Muscle
- Visceral Fascia
- Bone Tissue
- Hormone Receptor Expression in Human Fascial Tissue
Should we beware the tyranny of the randomized controlled trial? | Association of Health Care Journalists – by Tara Haelle (@TaraHaelle) – Jan 2017
The intersection of scientific research, evidence and expertise can be a dicey one, particularly in an age in which evidence-based medicine is replacing the clinical expertise of practitioners.
In The New York Times Sunday Review, Jamie Holmes wrote about how the challenge of assessing the quality of evidence against expertise and less stringently conducted research can lead readers to confusion and frustration.
It can lead to a further distrust of science, Holmes suggested, noting the example of dental flossing in the wake of an Associated Press story that questioned the evidence in favor of the practice. Continue reading
Long-term opioid therapy in chronic noncancer pain. NIH – Feb 2015 – a systematic review and meta-analysis of efficacy, tolerability, and safety in open-label extension trials with a study duration of at least 26 weeks (that’s 1/2 year).
This study confirms what pain patients all know: long-term opioids are effective for long-term pain, require few increases, and only rarely result in “opioid use disorder”.
The efficacy and safety of long-term (≥ 6 months) opioid therapy (LtOT) in chronic noncancer pain (CNCP) is under debate.A systematic review with meta-analysis of the efficacy and harms of opioids in open-label extension studies of randomized controlled trials (RCTs) has not been conducted until now. Continue reading
Opioids Continue to Be Effective Long Term – Medscape – Fran Lowry – October 01, 2013
This is a good review with results that ring true in my experience,
Unfortunately, it’s fatally tainted by funding from Purdue.
An extensive literature review of studies evaluating the effectiveness of long-term opioid therapy in chronic noncancer pain (CNCP) concludes that the drugs continue to provide reliable and safe analgesia for 6 months or more.
“Due to FDA regulatory guidelines, most contemporary phase 3 randomized controlled trials of opioid analgesics for CNCP are 3 months long or less. Continue reading