Tag Archives: research

Role of Stress Gene in Chronic Pain

Researchers Elucidate Role of Stress Gene in Chronic Pain – from NIH – Posted on  by 

For most people, pain eventually fades away as an injury heals. But for others, the pain persists beyond the initial healing and becomes chronic, hanging on for weeks, months, or even years.

Now, we may have uncovered an answer to help explain why: subtle differences in a gene that controls how the body responds to stress.

In a recent study of more than 1,600 people injured in traffic accidents, researchers discovered that individuals with a certain variant in a stress-controlling gene, called FKBP5, were more likely to develop chronic pain than those with other variants.   Continue reading

Tapentadol: for acute and chronic pain

Here are excerpts from 5 PubMed studies on tapentadol (an atypical opioid):

Tapentadol Prolonged Release for Chronic Pain: A Review of Clinical Trials and 5 Years of Routine Clinical Practice Data. – PubMed – NCBI – Pain Pract. June 2017

Tapentadol prolonged release (PR) for the treatment of moderate to severe chronic pain combines 2 modes of action.

These are μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule that allow higher analgesic potency through modulation of different pharmacological targets within the pain-transmitting systems.   Continue reading

Study Shows How Aspirin Fights Inflammation

Study Shows How Aspirin Fights Inflammation – National Pain Report

A daily low-dose aspirin has long been recommended by doctors for its cardiovascular benefits.

But only now are researchers getting a better understanding of how aspirin reduces the inflammation that can lead to heart disease and other chronic health conditions.

So, doctors were recommending something even though they didn’t know its mechanism of action. I always thought it worked because it thinned the blood.    Continue reading

Promising Results Finding Non-addictive Pain Killer

Scientists Take Big step Toward Finding Non-addictive Pain Killer – Aug 2018 – Wake Forest Baptist Medical Center

scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country

Known as AT-121, the new chemical compound has dual therapeutic action that suppressed the addictive effects of opioids and produced morphine-like analgesic effects in non-human primates.

How well the results will hold up in humans is always a question that remains unasked as these new drugs are touted as breakthroughs.   Continue reading

The Limits of Prescription Control

A Crisis of Opioids and the Limits of Prescription Control – by Stefan G. Kertesz and Adam J. Gordon – 23 July 2018

A rise in addiction and overdose deaths involving opioids in the United States has spurred a series of initiatives focused on reducing opioid risks, including several related to prescription of opioids in care of pain. Policy analytic scholarship provides a conceptual framework to assist in understanding this response.

Prior to 2011, a “policy monopoly” of regulators and pharmaceutical manufacturers allowed and encouraged high levels of opioid prescribing.

The authors then point out that the debate has been cornered by an “advocacy coalition” of anti-opioid fanatics:  Continue reading

New painkillers could thwart opioids’ fatal flaw

New painkillers could thwart opioids’ fatal flaw | Science | AAAS– Nov 2017 – By Meredith Wadman

When people die from overdoses of opioids, whether prescription pain medications or street drugs, it is the suppression of breathing that almost always kills them.

The drugs act on neuronal receptors to dull pain, but those in the brain stem also control breathing. When activated, they can signal respiration to slow, and then stop.

Countering this lethal side effect without losing opioids’ potent pain relief is a challenge that has enticed drug developers for years.   Continue reading

Nora Volkow on why opioids are unique

Nora Volkow on MAT, naloxone, new drugs, and why opioids are unique – Opioid Watch – Nonprofit News from The Opioid Research Institute – July 2018

This is part 2 (part 1 here) of an interview with research psychiatrist Nora Volkow, MD, the director of the National Institute on Drug Abuse for the past 15 years.

  • Q: You are a pioneer in the use of brain scans to study addiction. At the level of brain chemistry, how is opioid addiction similar to other addictions, and how does it differ?

Addictive drugs can orchestrate a state of positive affect, an experience that, for some people, can be more powerful and/or compelling than that produced by natural rewards, like food or sex.  

Continue reading

Opioid Combination Shows Promise for Safer Pain Relief

In Animals, Opioid Combination Shows Promise for Safer Pain Relief  – June 2018 – from NIDA

Spurred by the epidemic of opioid overdoses and deaths in the United States, researchers are seeking new formulations of opioid pain relievers that will reduce the medications’ potential for misuse and overdose without compromising their analgesic effectiveness.

In one such effort, NIDA-funded researchers recently tested a combination of the prescription analgesic oxycodone and nalfurafine, which is used in Japan to treat itching associated with hemodialysis and chronic liver disease.

In the body, pain and itch are processed in very similar ways: they share a common pathway positioned in the spinal cord and also activate the same sensory brain areas. Continue reading

Latest review of Opioid-Induced Hyperalgesia

Latest review of Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review. – PubMed – NCBI – Am J Ther. – Jan 2018

BACKGROUND:

Opioid-induced hyperalgesia (OIH) is a phenomenon that causes an increased pain sensitization and perception of pain to noxious stimuli secondary to opioid exposure.

While this clinical effect has been described in the surgical setting, it is unclear if OIH occurs in the nonsurgical setting.

Yet, some doctors are quick to blame any pain patient’s increased pain on this mythical phenomenon. Instead of prescribing more opioids, they use your additional pain as an excuse to cry “OIH!” and taper you down.   Continue reading

Looking to mosquitoes for painless injections

Looking to mosquitoes for a way to develop painless microneedles – June 2018 – Source Newsroom: Ohio State University

A mosquito can insert a needle-like probe into your skin and draw blood for several minutes without you even noticing.

Researchers at The Ohio State University believe we can learn from nature’s design of the mosquito to create a painless microneedle for medical purposes.

In a recently published paper, Bhushan and his colleagues reported on their detailed analysis of the mosquito’s proboscis – the part that feeds on us.   Continue reading