This PubMed article piqued my interest because of the following paragraphs which seem an uncanny description of the hyper-sensitivity that so many of us suffer from.
It may be that people with ADHD are afflicted with a defective filtering system such that their brainstem reticular formation does not block out irrelevant stimuli. These people appear to be aware of every sound, every object, every touch, and they all merge in disorganized behaviors that are difficult to tolerate
At a deeper level, ADHD is a problem of communication among brain cells, or neurons, possibly involving the neurotransmitters that carry inter-neural messages. If the messengers that inhibit incoming stimuli are deficient, too many signals get through and create confusion.
Attention-deficit-hyperactivity disorder and reward deficiency syndrome – free full-text PMC2626918 – 2008 Oct; Continue reading
C-reactive protein and cold-pressor tolerance in the general population : PAIN – July 2017
Pain and inflammation are related: systemic inflammation may lead to a variety of pain states, and, in turn, persistent pain causes an upward adjustment of proinflammatory mediators that sometimes elicit a prolonged low-grade immune response, leading to long-lasting, subclinical inflammation.
The cytokines that are produced during inflammatory responses are the main stimulators of the production of acute-phase proteins, specifically C-reactive protein (CRP).
C-reactive protein is a nonspecific systemic marker of infection, inflammation, tissue damage, malignancy, and autoimmune disease.
Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects – 2006 May – free full-text PMC1459894
This meta-analysis was carried out with these objectives:
- to compare the efficacy of opioids for CNCP with other drugs and placebo;
- to identify types of CNCP that respond better to opioids; and
- to determine the most common side effects of opioids. Continue reading
Statistics and the Rise of Medical Fortunetellers – Michel Accad, MD – Tex Heart Inst J. 2009; free full-text PMC2801944
This article makes the increasingly forgotten, yet increasingly important, point that population statistics do NOT apply to individuals.
There was a time when the foretelling of future events was an undertaking of prophets, palm-readers, and weathermen. In recent years, however, the medical profession seems to have embraced this activity with a great deal of enthusiasm.
But hyperbole is also what comes to mind when one examines the claims that authors of such reports make. Continue reading
How Systematic Review and Meta-Analysis Work | American Council on Science and Health -By Chuck Dinerstein — June 23, 2017
…I thought perhaps this was a time to explain systematic reviews (SR) and their closely related kin, the meta-analysis (MA).
Keeping up with the latest thinking and knowledge, even for specialists, is challenging.
Textbooks, given the time necessary to write, edit and print are repositories for the accepted ‘dogma.’
Journals and conferences bring new information forward more quickly. But even then it is difficult for individuals to synthesize multiple articles and sources to ‘know’ what is both correct and useful. Continue reading
Surrogate end points in clinical research: hazardous to your health. – PubMed – NCBI – Obstet Gynecol. 2005 May
Surrogate end points in clinical research pose real danger.
A surrogate end point is an outcome measure, commonly a laboratory test, that substitutes for a clinical event of true importance.
Resistance to activated protein C, for example, has been used as a surrogate for venous thrombosis in women using oral contraceptives.
Other examples of inappropriate surrogate end points in contraception include the Continue reading
Unexpected mechanism behind chronic nerve pain | News | News | Karolinska Institutet
It has long been assumed that chronic nerve pain is caused by hypersensitivity in the neurons that transmit pain.
Researchers at Karolinska Institutet in Sweden now show that another kind of neuron that normally allows us to feel pleasant touch sensation, can switch function and instead signal pain after nerve damage.
The results, which are presented in the journal Science, can eventually lead to more effective pain treatments. Continue reading
Cells carry ‘memory’ of injury, which could reveal why chronic pain persists | EurekAlert! Science News – May-2016
A new study from King’s College London offers clues as to why chronic pain can persist, even when the injury that caused it has gone.
Although still in its infancy, this research could explain how small and seemingly innocuous injuries leave molecular ‘footprints’ which add up to more lasting damage, and ultimately chronic pain.
While chronic pain can have many different causes, the outcome is often the same: an overly sensitive nervous system which responds much more than it normally would. Continue reading
Individual differences in pain: understanding the mosaic that makes pain personal: PAIN – – Fillingim, Roger B. – Pain: April 2017
In Brief: The experience of pain is characterized by tremendous interindividual variability, which is driven by multiple biopsychosocial factors.
This review article discusses individual differences in pain, including the roles of demographic, genetic, and psychosocial factors and their interactions
The public can only access the first page of this report as a JPEG picture, but if you enlarge it you can read the text (even though it seems to have been intentionally blurred). Continue reading
Quackery infiltrates The BMJ – Science-Based Medicine – David Gorski – May 22, 2017
Is LACK of EVIDENCE the same as/equate to QUAKERY?
We here have long lamented the creeping infiltration of quackery into medical academia in which modalities once considered quackery, such as
- reiki, naturopathy,
- homeopathy, and
- various other dubious treatments,
have found their way into what should be bastions of science-based medicine (SBM). Continue reading