Benefits of GABA Supplementation

3 Amazing Benefits of GABA | Psychology Today – Michael J Breus Ph.D. – Posted Jan 03, 2019

GABA is both a chemical produced within the body and a supplement that’s made for ingestion.

Many medications interact with GABA and GABA receptors in the brain, altering their function to achieve certain effects, typically

  • relaxation,
  • pain relief,
  • stress and anxiety reduction,
  • lower blood pressure, and
  • improved sleep.

Barbiturates, anesthetics, benzodiazepines, antidepressants, and anti-seizure medications are some of the medications that target GABA.

GABA supplements are often used to treat high blood pressure, stress and anxiety, and sleep, as well as to stimulate the body’s natural growth hormone, often by athletes.

How does GABA work?

I call GABA the brakes of the brain.

And I certainly need brakes on my hyperactive brain!

It is the body’s most important inhibitory neurotransmitter, which means it lowers the activity of neural cells in the brain and central nervous system, having the effect of moving the brain and the body into lower gear.

GABA also plays an important role in regulating muscle tone.

In combination with glutamate, the body’s most important excitatory neurotransmitter, GABA is an important contributor to the body’s overall mental and physical homeostasis, or balance.

Low GABA activity in the body can result in:

  • Anxiety.
  • Chronic stress.
  • Depression.
  • Difficulty concentrating and memory problems.
  • Muscle pain and headaches.
  • Insomnia and other sleep problems.

Low GABA activity is also associated with substance use disorders.

scientists have not reached consensus about whether, or how effectively, supplemental GABA crosses what’s known as the blood-brain barrier

Below, I’ll discuss what science tells us today about the potential effectiveness of GABA supplements for sleep and other conditions

Benefits of GABA

For sleep:

The body’s own GABA activity is important for sleep. GABA enables the body and mind to relax and fall asleep, and to sleep soundly throughout the night.

Sleep medications including those with zolpidem (Ambien and others) and eszopiclone (Lunesta and others) target the body’s GABA system to increase sedation and sleep.

For stress and anxiety:

As a natural chemical the body produces, GABA’s primary role is to diminish the activity of neurons in the brain and central nervous system, which puts the body in a greater state of relaxation and alleviates stress and anxiety

some studies have shown GABA to be effective in lowering anxiety and boosting relaxation. One small study of 13 adults showed GABA to be effective as a relaxant and anxiety reliever, with slowed brain waves seen within an hour of taking the supplement.

For high blood pressure:

GABA supplements are sometimes used by people as a natural way to lower blood pressure.

In one study of people with borderline high blood pressure, 12 weeks of use of the supplement chlorella, a type of algae rich in GABA, significantly lowered blood pressure.


The following doses are based on amounts that have been investigated in scientific studies:

  • For sleep, stress and anxiety: 100-200 mg and higher doses, in scientific studies. Individual dosing and length of use will vary.
  • For high blood pressure: 10-20 mg, in scientific studies.

Possible side effects

GABA oral supplements are generally well tolerated by healthy adults. Some people may experience negative side effects, including:

  • Gastric distress.
  • Nausea.
  • Diminished appetite.
  • Constipation.
  • Burning throat.
  • Drowsiness and fatigue.
  • Muscle weakness.
  • Shortness of breath, at very high doses.

Below is a more recent article from a respected institution, also showing promise for GABA supplementation:

Gaba Supplements: Glorious, Gimmicky or Just Garbage? | Office for Science and Society – McGill UniversityAda McVean B.Sc. | 11 Oct 2018

GABA is an important neurotransmitter and GABAergic drugs are crucial for a variety of conditions, but GABA supplements (including GABA tea) might just be useless.

Take-home message:

– gamma-Aminobutyric acid (GABA) is a major neurotransmitter that regulates much of our brain function. It was previously thought that ingested GABA could not cross the blood-brain barrier, but new research suggests that it may be able to.

– Drugs that mimic the action of GABA are numerous, work in a variety of ways, and can have effects ranging from treating epilepsy to causing it.

– GABA supplements have shown some promise in early, small-scale studies, but a lot more research is needed to know if they truly help.

5 thoughts on “Benefits of GABA Supplementation

  1. Kathy C

    I think that if any of these supplements actually worked, it would be a real discovery. I have serious doubts, and attribute the perceived benefits to the same factors as other supplements. This stuff has been cleverly marketed, that is all. Also we don;t een know if any of these supplements even contain a useful compound that the body can absorb. Health marketing is a free for all, there are no regulations on the marketing or on any agency to determine what compound is even being sold. Athletes endorse all kinds of gimmicky treatments, and when they are found dangerous or useless, the public never hears about it.


    1. Zyp Czyk Post author

      It’s always helpful to get anecdotal responses. Can you tell us in what ways it helped? Pain, depression, anxiety?

      I believe I’m noticing a lessening of my anxiety on the days I use it (75mg Lyrica), but I haven’t gone back and parsed my detailed health diary to find my anxiety level on days with or without Lyrica – that’s a lot of work! But at least I know the data is there if the issue becomes more important.


      1. Shawn M Moore

        It helps lessen my anxiety SOOO much!
        No more of that useless (for me)Buspar. I take a capsule very early AM(around 5).
        I wish more people knew about it. 💖

        Liked by 1 person

        1. Zyp Czyk Post author

          Anxiety is my greatest, most powerful daemon, so I’m glad to hear that someone else is getting relief from a drug I have access to.

          I was offered Buspar first and it had strange effects on my mind/mood. It seemed to loosen the anxiety just a little, but it also pushed me into an unusual (for me) kind of depression. About 4 hours after I took it, I was taken over by fits of crying.

          But, my anxiety gets so bad it becomes a survival issue and I had to use the Buspar because that’s all I had. By comparison, the weepy depression was much, much easier to tolerate. I’ll take depression over anxiety any day!

          However, I found the best relief from pregnenolone. Studies were done using up to 500mg daily, so I started with 300 and for now I think 200mg is enough

          Here’s the link for the search you can do on EDSinfo to find all my posts about it:

          I’m always happy to find a helpful substance that doesn’t require a doctors permission slip (prescription).



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