CDC’s Flawed Opioid Efforts

Drugwonks | CDC’s Flawed Opioid Efforts. Attention must be paid.

Peter Pitts compiled a list of statements made by various medical associations that express strong disagreement with both the process and substance of the CDC opioid prescribing guidelines:

When it comes to the CDC’s new opioid guidelines, attention must be paid — immediately and publicly. This is the message from a growing constituency of physicians, patients and policy experts concerned and upset about both the CDC’s conflict-ridden, secretive process and, even more importantly, the guidelines themselves. Continue reading

Wrong diagnoses very common

Most Americans will get a wrong or late diagnosis at least once in their lives – The Washington Post

Most Americans who go to the doctor will get a diagnosis that is wrong or late at least once in their lives, sometimes with terrible consequences, according to a report released Tuesday by an independent panel of medical experts

This critical type of health-care error is far more common than medication mistakes or surgery on the wrong patient or body part. But until now, diagnostic errors have been a relatively understudied and unmeasured area of patient safety.   Continue reading

The Endocannabinoid System

Introduction to the Endocannabinoid System

As you read this review of the scientific literature regarding the therapeutic effects of cannabis and cannabinoids, one thing will become quickly evident: cannabis has a profound influence on the human body. This one herb and its variety of therapeutic compounds seem to affect every aspect of our bodies and minds.

At the time of updating (February 2015), a PubMed search for scientific journal articles published in the last 20 years containing the word “cannabis” revealed 8,637 results. Add the word “cannabinoid,” and the results increase to 20,991 articles. Continue reading

Opioid-Induced Androgen Deficiency

Opioid-Induced Androgen Deficiency: Pharmacist Counseling Points

Opioid-induced androgen deficiency (OPIAD) is a common yet under diagnosed adverse effect of chronic opioid use.

Hypogonadism is frequently seen with opioid use and can occur quickly; however, it is generally considered reversible.

Before we discuss the OPIAD phenomenon, let’s explore how testosterone and estrogen are produced and regulated by the body.   Continue reading

The Link Between Empathy and Pain

The Link Between Empathy and Pain  

New research suggests empathy may be a lot more complicated than we think – at least when it comes to feeling the pain of others.

A team of European researchers has found evidence that empathy may be strongly influenced by neurotransmitters in the brain — and is not just a form of emotional or social bonding.

Their findings suggest that empathy is dependent – not on feeling the pain of others — but on experiencing pain yourself.   Continue reading

Neurodevelopmental attributes of joint hypermobility/EDS

Neurodevelopmental attributes of joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type: Update and perspectives – Ghibellini – 2015 – American Journal of Medical Genetics 

In the last decade, increasing attention has been devoted to the extra-articular and extra-cutaneous manifestations of joint hypermobility syndrome, also termed Ehlers–Danlos syndrome, hypermobility type (i.e., JHS/EDS-HT)

Despite the fact that the current diagnostic criteria for both disorders remain focused on joint hypermobility, musculoskeletal pain and skin changes, medical practice and research have started investigating a wide spectrum of visceral, neurological and developmental complications, which represent major burdens for affected individuals.   Continue reading

Fibromyalgia Symptoms of Systemic Dysfunction

Do You Have These Fibromyalgia Symptoms of Systemic Dysfunction?
By Sue Ingebretson

For those of us with fibromyalgia and other related chronic health challenges, the symptoms we experience run the gamut. From annoying facial tics to whole body pain, it’s hard to pin down where one symptom ends and another begins.

If there’s any collection of symptoms that most of us with fibromyalgia understand, it’s our tendency toward hyper-sensitivity.

We’re super-sensitive to sights (lights), sounds, smells, foods, chemicals (airborne, dietary, topical), touch, the stressful energy surrounding others, and more.   Continue reading

Non-inherited mutations in somatic cells

A Natural History of Neurons | HMS

This study is evidence that somatic mutations may contribute to a range of neurodevelopmental and neurodegenerative diseases

As we grow, our brain cells develop different genomes from one another, according to new research from Harvard Medical School and Boston Children’s Hospital.

The study, published Oct. 2 in Science, shows for the first time that mutations in somatic cells—that is, any cell in the body except sperm and eggs—are present in significant numbers in the brains of healthy people. This finding lays the foundation for exploring the role of these post-conception mutations in human development and disease.   Continue reading

Miscellaneous Research on EDS/BJHS


Prevalence, injury rate and, symptom frequency in generalized joint laxity and joint hypermobility syndrome in a “healthy” college population Russek, Leslie N. · Errico, M. Deanna in Clinical Rheumatology (2015)

Is pain the only symptom in patients with benign joint hypermobility syndrome? Albayrak, İlknur · Yilmaz, Halim · Akkurt, Halil Ekrem, et al. in Clinical Rheumatology (2014)

Joint hypermobility syndrome pain Grahame, Rodney in Current Pain and Headache Reports (2009)   Continue reading

EDS Hypermobility Type and Gastrointestinal Symptoms

PP-5 Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type and Gastrointestinal Symptoms. : Journal of Pediatric Gastroenterology and Nutrition – Free Article

October 2015 – Volume 61 – Issue 4 – p 522

I could not find the full text using the links provided, but even the abstract provides evidence of an association. Continue reading