Brain abnormalities are Consequence Not Cause of pain

Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain | Journal of Neuroscience Nov 2009

If you can reverse brain “damage” by effectively treating the patient’s chronic pain, it seems pretty clear that the chronic pain was the cause.

This means we don’t have to accept the idea that abnormalities in our brains are what’s causing our pain (which some have hinted at).

Recently, local morphologic alterations of the brain in areas ascribable to the transmission of pain were reported in patients suffering from chronic pain.

Although some authors discussed these findings as damage or loss of brain gray matter, one of the key questions is whether these structural alterations in the cerebral pain-transmitting network precede or succeed the chronicity of pain.  

We investigated 32 patients with chronic pain due to primary hip osteoarthritis and found a characteristic gray matter decrease in patients compared with controls in the

  • anterior cingulate cortex (ACC),
  • right insular cortex and operculum,
  • dorsolateral prefrontal cortex (DLPFC),
  • amygdala, and
  • brainstem.

We then investigated a subgroup of these patients (n = 10) 6 weeks and 4 months after total hip replacement surgery, monitoring whole brain structure.

After surgery, all 10 patients were completely pain free and we observed a gray matter increase in the

  • DLPFC,
  • ACC,
  • amygdala, and
  • brainstem.

As gray matter decrease is at least partly reversible when pain is successfully treated, we suggest that the gray matter abnormalities found in chronic pain do not reflect brain damage but rather are a reversible consequence of chronic nociceptive transmission, which normalizes when the pain is adequately treated.


Using VBM we found significant differences in CNS gray matter in chronic pain patients due to primary hip osteoarthritis (Fig. 1), which fall into two broad groups:

(1) areas showing a decrease in gray matter comparing the chronic pain state in patients and pain-free controls mainly involving the ACC, DLPFC, amygdala, insular cortex, orbital gyrus, and brainstem; and

(2) areas showing an increase in gray matter over time after pain relief in a subgroup of these patients, such as the ACC, DLPFC, amygdala, brainstem, and insular cortex.

These data suggest that prolonged nociceptive input due to primary hip osteoarthritis leads to an alteration in morphology and/or cytoarchitecture of anterograde projection areas, which partly recede when the patient is pain free after endoprosthetic joint replacement surgery.

At least in these patients, it is unlikely that repeated nociceptive input leading to chronicity of pain over time results in irreversible “damage” and/or “atrophy” to the brain.

6 thoughts on “Brain abnormalities are Consequence Not Cause of pain

  1. canarensis

    I remember reading about pain shrinking the brain. Add that to depression shrinking the brain, & I’m surprised I can’t hear my brain rattling around in my skull like a BB in an empty tuna can.

    Liked by 3 people

      1. canarensis

        I hear you, my friend. Though if the way you write & analyze the papers in your blog happen using your wet cement, I cannot imagine how amazing your thought processes are when they are/were at the top of your form! Impressive.

        Liked by 2 people

  2. Pingback: Treating chronic pain can restore normal brain function | EDS and Chronic Pain News & Info

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